Reactome | WLS binds WNT ligands in the Golgi

Schema > Reaction > Entries

WLS binds WNT ligands in the Golgi Show undefined attributes

authored	[InstanceEdit:3247883] Rothfels, K, 2013-04-05
category	binding
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:3247846] Rothfels, K, 2013-04-05
dbId	3247840
displayName	WLS binds WNT ligands in the Golgi
edited	[InstanceEdit:3451017] Matthews, L, 2013-04-12
eventOf	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3247844] WNT ligands traffic to the plasma membrane - Homo sapiens
input	[CandidateSet:R-HSA-3247824] palmitoleyl-N-glycosylated WNTs [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-3247747] WLS [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3247698] Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells [LiteratureReference:3247735] Secretion of Wnt ligands requires Evi, a conserved transmembrane protein [LiteratureReference:3247716] Sprinter: a novel transmembrane protein required for Wg secretion and signaling [LiteratureReference:3247723] WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification [LiteratureReference:3247710] Porcupine-mediated lipidation is required for Wnt recognition by Wls
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WLS binds WNT ligands in the Golgi
orthologousEvent	[Reaction:R-CEL-3247840] WLS binds WNT ligands in the Golgi - Caenorhabditis elegans [Reaction:R-DME-3247840] WLS binds WNT ligands in the Golgi - Drosophila melanogaster [Reaction:R-GGA-3247840] WLS binds WNT ligands in the Golgi - Gallus gallus [Reaction:R-XTR-3247840] WLS binds WNT ligands in the Golgi - Xenopus tropicalis [Reaction:R-DRE-3247840] WLS binds WNT ligands in the Golgi - Danio rerio [Reaction:R-SSC-3247840] WLS binds WNT ligands in the Golgi - Sus scrofa [Reaction:R-BTA-3247840] WLS binds WNT ligands in the Golgi - Bos taurus [Reaction:R-CFA-3247840] WLS binds WNT ligands in the Golgi - Canis familiaris [Reaction:R-RNO-3247840] WLS binds WNT ligands in the Golgi - Rattus norvegicus [Reaction:R-MMU-3247840] WLS binds WNT ligands in the Golgi - Mus musculus
output	[Complex:R-HSA-3247841] WLS:WNT [Golgi membrane]
precedingEvent	[BlackBoxEvent:R-HSA-3247837] WNT ligands traffic to the Golgi - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3621851] Boutros, Michael, 2013-05-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3247840
summation	[Summation:3247772] Wntless (WLS) (Evi/Sprinter/GPR177) is a conserved transmemb...

Referrals

(hasEvent)	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking
(precedingEvent)	[BlackBoxEvent:R-HSA-3247844] WNT ligands traffic to the plasma membrane