Reactome | WNT ligands traffic to the plasma membrane

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WNT ligands traffic to the plasma membrane Show undefined attributes

authored	[InstanceEdit:3247883] Rothfels, K, 2013-04-05
category	omitted
compartment	[Compartment:20699] Golgi membrane [Compartment:876] plasma membrane
created	[InstanceEdit:3247846] Rothfels, K, 2013-04-05
dbId	3247844
displayName	WNT ligands traffic to the plasma membrane
edited	[InstanceEdit:3451017] Matthews, L, 2013-04-12
eventOf	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3781943] WLS:WNT complex is internalized for maturation into exosomes - Homo sapiens [Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
input	[Complex:R-HSA-3247841] WLS:WNT [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3247698] Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells [LiteratureReference:3247735] Secretion of Wnt ligands requires Evi, a conserved transmembrane protein [LiteratureReference:3247716] Sprinter: a novel transmembrane protein required for Wg secretion and signaling
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	WNT ligands traffic to the plasma membrane
orthologousEvent	[BlackBoxEvent:R-CEL-3247844] WNT ligands traffic to the plasma membrane - Caenorhabditis elegans [BlackBoxEvent:R-DME-3247844] WNT ligands traffic to the plasma membrane - Drosophila melanogaster [BlackBoxEvent:R-GGA-3247844] WNT ligands traffic to the plasma membrane - Gallus gallus [BlackBoxEvent:R-XTR-3247844] WNT ligands traffic to the plasma membrane - Xenopus tropicalis [BlackBoxEvent:R-SSC-3247844] WNT ligands traffic to the plasma membrane - Sus scrofa [BlackBoxEvent:R-BTA-3247844] WNT ligands traffic to the plasma membrane - Bos taurus [BlackBoxEvent:R-CFA-3247844] WNT ligands traffic to the plasma membrane - Canis familiaris [BlackBoxEvent:R-RNO-3247844] WNT ligands traffic to the plasma membrane - Rattus norvegicus [BlackBoxEvent:R-MMU-3247844] WNT ligands traffic to the plasma membrane - Mus musculus
output	[Complex:R-HSA-3247838] WLS:WNT [plasma membrane]
precedingEvent	[Reaction:R-HSA-3247840] WLS binds WNT ligands in the Golgi - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3621851] Boutros, Michael, 2013-05-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3247844
summation	[Summation:3247767] WLS accompanies WNT through the secretory pathway to the cel...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-3781943] WLS:WNT complex is internalized for maturation into exosomes [Reaction:R-HSA-3247843] secretion of WNT ligands
(hasEvent)	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking