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Schema
>
BlackBoxEvent
>
Entries
WNT ligands traffic to the Golgi
Show undefined attributes
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authored
[InstanceEdit:3247883] Rothfels, K, 2013-04-05
category
omitted
compartment
[Compartment:17963] Golgi lumen
[Compartment:17957] endoplasmic reticulum lumen
created
[InstanceEdit:3247846] Rothfels, K, 2013-04-05
dbId
3247837
displayName
WNT ligands traffic to the Golgi
edited
[InstanceEdit:3451017] Matthews, L, 2013-04-12
eventOf
[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking - Homo sapiens
followingEvent
[Reaction:R-HSA-3247840] WLS binds WNT ligands in the Golgi - Homo sapiens
input
[CandidateSet:R-HSA-3238374] palmitoleyl-N-glycosylated WNTs [endoplasmic reticulum lumen]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199973] Secretory protein trafficking and organelle dynamics in living cells
[LiteratureReference:3247722] Protein sorting receptors in the early secretory pathway
[LiteratureReference:3247700] A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion
[LiteratureReference:3247709] p24 proteins are required for secretion of Wnt ligands
[LiteratureReference:3247728] The p24 family and selective transport processes at the ER-Golgi interface
[LiteratureReference:3247879] Wnts need a p(assport)24 to leave the ER
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
WNT ligands traffic to the Golgi
orthologousEvent
[BlackBoxEvent:R-CEL-3247837] WNT ligands traffic to the Golgi - Caenorhabditis elegans
[BlackBoxEvent:R-DME-3247837] WNT ligands traffic to the Golgi - Drosophila melanogaster
[BlackBoxEvent:R-GGA-3247837] WNT ligands traffic to the Golgi - Gallus gallus
[BlackBoxEvent:R-XTR-3247837] WNT ligands traffic to the Golgi - Xenopus tropicalis
[BlackBoxEvent:R-DRE-3247837] WNT ligands traffic to the Golgi - Danio rerio
[BlackBoxEvent:R-SSC-3247837] WNT ligands traffic to the Golgi - Sus scrofa
[BlackBoxEvent:R-BTA-3247837] WNT ligands traffic to the Golgi - Bos taurus
[BlackBoxEvent:R-CFA-3247837] WNT ligands traffic to the Golgi - Canis familiaris
[BlackBoxEvent:R-RNO-3247837] WNT ligands traffic to the Golgi - Rattus norvegicus
[BlackBoxEvent:R-MMU-3247837] WNT ligands traffic to the Golgi - Mus musculus
output
[CandidateSet:R-HSA-3247824] palmitoleyl-N-glycosylated WNTs [Golgi lumen]
precedingEvent
[Reaction:R-HSA-3238694] PORCN palmitoleoylates N-glycosyl WNTs - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-3247850] Positive regulation by 'TMED5 [endoplasmic reticulum membrane]'
regulationReference
[RegulationReference:9642115] Positive regulation by 'TMED5 [endoplasmic reticulum membrane]' p24 proteins are required for secretion of Wnt ligands
releaseDate
2013-06-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3621851] Boutros, Michael, 2013-05-24
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-3247837
summation
[Summation:3247763] This black box event represents the non-WNT-specific ER-to-G...
Referrals
(hasEvent)
[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking
(precedingEvent)
[Reaction:R-HSA-3247840] WLS binds WNT ligands in the Golgi
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