Wntless (WLS) (Evi/Sprinter/GPR177) is a conserved transmemb...

created [InstanceEdit:3247773] Rothfels, K, 2013-04-05
dbId 3247772
displayName Wntless (WLS) (Evi/Sprinter/GPR177) is a conserved transmemb...
modified [InstanceEdit:3621894] Rothfels, K, 2013-05-24
schemaClass Summation
text Wntless (WLS) (Evi/Sprinter/GPR177) is a conserved transmembrane protein that is required for the secretion of WNT ligands from the cell (Bänzinger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006). Notably, WLS is not required for the secretion of Hedgehog, another acylated signaling molecule, and wls-mutants phenocopy wg/wnt mutants (Bänziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006), supporting the notion that WLS is a dedicated WNT pathway member. WLS binds directly to WNT ligands in the Golgi in a WNT-acylation dependent manner, as the interaction is abrogated by mutation of either PORCN or the conserved Ser209 residue (Coombs et al, 2010; Herr and Basler, 2012). WLS is thought to contain a lipocalin-family fold (Coombs et al, 2010), a lipid-interacting domain, which may play a role in binding to the lipid adduct on WNT.
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