WNT ligands traffic to the Golgi

Stable Identifier
R-HSA-3247837
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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This black box event represents the non-WNT-specific ER-to-Golgi trafficking step of protein secretion (reviewed in Dancourt and Barlowe, 2010; Lippincott Schwatz et al, 2000; for more details, please refer to the pathway "ER to Golgi transport"). Two recent screens in Drosophila have identified members of the p24 family as WNT-specific regulators of ER-to-Golgi transport, although the details have not been elucidated (Port et al, 2011; Buechling et al, 2011; reviewed in Strating and Martens, 2009). Depletion of the Drosophila p24 protein Opossum causes accumulation of WNT ligand in the ER, suggesting a role for Opm in ER-to-Golgi transport of WNTs. WNT-dependent reporter activity was reduced in HEK293 cells that were depleted for the human p24 homologue TMED5, supporting a conserved role for these proteins in WNT signaling (Buechling et al, 2011; reviewed in Palmer et al, 2012).

Literature References
PubMed ID Title Journal Year
20533886 Protein sorting receptors in the early secretory pathway

Dancourt, J, Barlowe, C

Annu. Rev. Biochem. 2010
22094269 p24 proteins are required for secretion of Wnt ligands

Buechling, T, Chaudhary, V, Spirohn, K, Weiss, M, Boutros, M

EMBO Rep. 2011
22094272 Wnts need a p(assport)24 to leave the ER

Palmer, L, Vincent, JP, Beckett, K

EMBO Rep. 2011
11031247 Secretory protein trafficking and organelle dynamics in living cells

Lippincott-Schwartz, J, Roberts, TH, Hirschberg, K

Annu Rev Cell Dev Biol 2000
21886182 A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion

Port, F, Hausmann, G, Basler, K

EMBO Rep. 2011
19566487 The p24 family and selective transport processes at the ER-Golgi interface

Strating, JR, Martens, GJ

Biol. Cell 2009
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This event is regulated
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