Reactome | PORCN palmitoleoylates N-glycosyl WNTs

Schema > Reaction > Entries

PORCN palmitoleoylates N-glycosyl WNTs Show undefined attributes

authored	[InstanceEdit:3247883] Rothfels, K, 2013-04-05
catalystActivity	[CatalystActivity:3238207] O-acyltransferase activity of PORCN [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:3238693] Rothfels, K, 2013-03-27
dbId	3238694
displayName	PORCN palmitoleoylates N-glycosyl WNTs
edited	[InstanceEdit:3451017] Matthews, L, 2013-04-12
eventOf	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3247837] WNT ligands traffic to the Golgi - Homo sapiens
inferredFrom	[Reaction:R-MMU-3238687] PORCN palmitoleoylates WNT3a - Mus musculus
input	[CandidateSet:R-HSA-3238268] N-glycosylated WNTs [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-3238096] palmitoleoyl-CoA [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases [LiteratureReference:3238093] Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion [LiteratureReference:3238086] Structural basis of Wnt recognition by Frizzled [LiteratureReference:3238083] Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a [LiteratureReference:3238084] The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing [LiteratureReference:3238090] Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein [LiteratureReference:3238075] A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling [LiteratureReference:3238087] Wnt proteins are lipid-modified and can act as stem cell growth factors [LiteratureReference:3238078] A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities [LiteratureReference:3247701] Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome [LiteratureReference:3247725] Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos [LiteratureReference:3247704] Precise regulation of porcupine activity is required for physiological Wnt signaling [LiteratureReference:3247710] Porcupine-mediated lipidation is required for Wnt recognition by Wls [LiteratureReference:3247729] Lipid-independent secretion of a Drosophila Wnt protein [LiteratureReference:3289763] Differential palmit(e)oylation of Wnt1 on C93 and S224 residues has overlapping and distinct consequences
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PORCN palmitoleoylates N-glycosyl WNTs
output	[SimpleEntity:R-ALL-162743] CoA-SH [endoplasmic reticulum lumen] [CandidateSet:R-HSA-3238374] palmitoleyl-N-glycosylated WNTs [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:R-HSA-3238691] N-linked glycosylation of WNTs - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3621851] Boutros, Michael, 2013-05-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3238694
summation	[Summation:3238689] All WNT proteins except Drosophila WntD are lipid modified. ...

Referrals

(hasEvent)	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking
(precedingEvent)	[BlackBoxEvent:R-HSA-3247837] WNT ligands traffic to the Golgi
(inferredTo)	[Reaction:R-MMU-3238687] PORCN palmitoleoylates WNT3a

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