Reactome | Active p38 MAPK phosphorylates MAPKAPK5

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Active p38 MAPK phosphorylates MAPKAPK5 Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:3239021] protein serine/threonine kinase activity of phospho-p38 MAPK: MAPKAPK5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3239020] Orlic-Milacic, M, 2013-03-27
dbId	3239019
displayName	Active p38 MAPK phosphorylates MAPKAPK5
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3239014] MAPKAPK5 phosphorylates TP53 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-3239009] phospho-p38 MAPK: MAPKAPK5 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3239000] PRAK, a novel protein kinase regulated by the p38 MAP kinase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Active p38 MAPK phosphorylates MAPKAPK5
orthologousEvent	[Reaction:R-RNO-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Rattus norvegicus [Reaction:R-PFA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Plasmodium falciparum [Reaction:R-GGA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Gallus gallus [Reaction:R-DRE-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Danio rerio [Reaction:R-SSC-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Sus scrofa [Reaction:R-BTA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Bos taurus [Reaction:R-MMU-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-3239017] phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3239019
summation	[Summation:3777049] MAPK14 (p38 alpha) and MAPK11 (p38 beta) phosphorylate MAPKA...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3239014] MAPKAPK5 phosphorylates TP53

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