Reactome | Active p38 MAPK phosphorylates MAPKAPK5

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Active p38 MAPK phosphorylates MAPKAPK5 Show undefined attributes

catalystActivity	[CatalystActivity:11117078] protein serine/threonine kinase activity of phospho-p38 MAPK: MAPKAPK5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11117080
displayName	Active p38 MAPK phosphorylates MAPKAPK5
eventOf	[Pathway:R-PFA-2559580] Oxidative Stress Induced Senescence - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-PFA-3239009] phospho-p38 MAPK: MAPKAPK5 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Active p38 MAPK phosphorylates MAPKAPK5
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-PFA-3239017] phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-3239019
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-2559580] Oxidative Stress Induced Senescence
(inferredTo)	[Reaction:R-HSA-3239019] Active p38 MAPK phosphorylates MAPKAPK5

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