Reactome | MAPKAPK5 phosphorylates TP53

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MAPKAPK5 phosphorylates TP53 Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:3239013] protein serine/threonine kinase activity of phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643518] protein serine/threonine kinase activity of phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] PRAK is essential for ras-induced senescence and tumor suppression
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3239020] Orlic-Milacic, M, 2013-03-27
dbId	3239014
displayName	MAPKAPK5 phosphorylates TP53
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3238986] PRAK is essential for ras-induced senescence and tumor suppression
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	MAPKAPK5 phosphorylates TP53
orthologousEvent	[Reaction:R-RNO-3239014] MAPKAPK5 phosphorylates TP53 - Rattus norvegicus [Reaction:R-DRE-3239014] MAPKAPK5 phosphorylates TP53 - Danio rerio [Reaction:R-SSC-3239014] MAPKAPK5 phosphorylates TP53 - Sus scrofa [Reaction:R-BTA-3239014] MAPKAPK5 phosphorylates TP53 - Bos taurus [Reaction:R-MMU-3239014] MAPKAPK5 phosphorylates TP53 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-3239015] p-S37-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Homo sapiens [Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3239014
summation	[Summation:3774866] Activated MAPKAPK5 (PRAK) phosphorylates TP53 (p53) on serin...

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