Reactome | SUMOylation of transcription factors

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SUMOylation of transcription factors Show undefined attributes

authored	[InstanceEdit:3222564] May, B, 2013-03-23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3232159] May, B, 2013-03-27
dbId	3232118
displayName	SUMOylation of transcription factors
doi	10.3180/R-HSA-3232118.6
edited	[InstanceEdit:3222564] May, B, 2013-03-23
eventOf	[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-3232162] PIAS3 SUMOylates MITF with SUMO1 - Homo sapiens [Reaction:R-HSA-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-3247493] PIAS1 SUMOylates SP3 with SUMO1 - Homo sapiens [Reaction:R-HSA-6804468] PIAS1 SUMOylates SP3 with SUMO2 - Homo sapiens [Reaction:R-HSA-2997723] PIAS4 SUMOylates TP53BP1 with SUMO1 - Homo sapiens [Reaction:R-HSA-2997706] MDM2 SUMOylates TP53 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Homo sapiens [Reaction:R-HSA-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Homo sapiens [Reaction:R-HSA-3234081] SUMOylation of TFAP2A with SUMO1 - Homo sapiens [Reaction:R-HSA-3234084] SUMOylation of TFAP2B with SUMO1 - Homo sapiens [Reaction:R-HSA-3234094] SUMOylation of TFAP2C with SUMO1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:4663795] Emerging roles of the SUMO pathway in development [LiteratureReference:4663777] Regulation of transcription factor activity by SUMO modification [LiteratureReference:4663804] A role for SUMO modification in transcriptional repression and activation [LiteratureReference:4663806] Something about SUMO inhibits transcription [LiteratureReference:4663799] SUMO and transcriptional regulation [LiteratureReference:4686128] SUMO association with repressor complexes, emerging routes for transcriptional control
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SUMOylation of transcription factors
orthologousEvent	[Pathway:R-SCE-3232118] SUMOylation of transcription factors - Saccharomyces cerevisiae [Pathway:R-SPO-3232118] SUMOylation of transcription factors - Schizosaccharomyces pombe [Pathway:R-DDI-3232118] SUMOylation of transcription factors - Dictyostelium discoideum [Pathway:R-CEL-3232118] SUMOylation of transcription factors - Caenorhabditis elegans [Pathway:R-DME-3232118] SUMOylation of transcription factors - Drosophila melanogaster [Pathway:R-GGA-3232118] SUMOylation of transcription factors - Gallus gallus [Pathway:R-XTR-3232118] SUMOylation of transcription factors - Xenopus tropicalis [Pathway:R-DRE-3232118] SUMOylation of transcription factors - Danio rerio [Pathway:R-SSC-3232118] SUMOylation of transcription factors - Sus scrofa [Pathway:R-BTA-3232118] SUMOylation of transcription factors - Bos taurus [Pathway:R-RNO-3232118] SUMOylation of transcription factors - Rattus norvegicus [Pathway:R-MMU-3232118] SUMOylation of transcription factors - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6803018] May, Bruce, 2015-10-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3232118
summation	[Summation:4663764] Proteins classified as transcription factors constitute a di...
updateTrackers	[UpdateTracker:9783332] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v57:[addHasEvent] [UpdateTracker:9774920] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v80:[updateContainedRLE] [UpdateTracker:9782937] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v58:[updateContainedRLE] [UpdateTracker:9782029] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v60:[addHasEvent] [UpdateTracker:9783491] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v56:[addHasEvent]

Referrals

(updatedInstance)

[UpdateTracker:9783332] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v57:[addHasEvent]
[UpdateTracker:9774920] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v80:[updateContainedRLE]
[UpdateTracker:9782937] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v58:[updateContainedRLE]
[UpdateTracker:9782029] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v60:[addHasEvent]
[UpdateTracker:9783491] Update Tracker - [Pathway:3232118] SUMOylation of transcription factors - v56:[addHasEvent]

(hasEvent)

[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins

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