Reactome | PIAS1,3,4 SUMOylate MTA1 with SUMO2,3

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PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 Show undefined attributes

authored	[InstanceEdit:3448699] May, B, 2013-05-16
catalystActivity	[CatalystActivity:3465549] SUMO transferase activity of PIAS1,3,4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643285] SUMO transferase activity of PIAS1,3,4 [nucleoplasm] SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3465543] May, B, 2013-05-17
dbId	3465545
displayName	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3
edited	[InstanceEdit:3448699] May, B, 2013-05-16
eventOf	[Pathway:R-HSA-3232118] SUMOylation of transcription factors - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:4162] protein sumoylation
input	[EntityWithAccessionedSequence:R-HSA-3465550] MTA1 [nucleoplasm] 2 × [DefinedSet:R-HSA-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3465552] SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PIAS1,3,4 SUMOylate MTA1 with SUMO2,3
orthologousEvent	[Reaction:R-DDI-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Dictyostelium discoideum [Reaction:R-DME-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-GGA-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Gallus gallus [Reaction:R-XTR-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Xenopus tropicalis [Reaction:R-DRE-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Danio rerio [Reaction:R-SSC-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Sus scrofa [Reaction:R-BTA-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Bos taurus [Reaction:R-RNO-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Rattus norvegicus [Reaction:R-MMU-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3465537] polySUMO2,3-K509-MTA1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6804455] Kumar, Rakesh, 2015-10-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3465545
summation	[Summation:4663786] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 at lysine-509 (Cong et...

Referrals

(hasEvent)

[Pathway:R-HSA-3232118] SUMOylation of transcription factors