Reactome | PIAS3 SUMOylates MITF with SUMO1

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PIAS3 SUMOylates MITF with SUMO1 Show undefined attributes

authored	[InstanceEdit:3222564] May, B, 2013-03-23
catalystActivity	[CatalystActivity:3232160] SUMO transferase activity of PIAS3 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643302] SUMO transferase activity of PIAS3 [nucleoplasm] Sumoylation of MITF and its related family members TFE3 and TFEB
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3232159] May, B, 2013-03-27
dbId	3232162
displayName	PIAS3 SUMOylates MITF with SUMO1
edited	[InstanceEdit:3222564] May, B, 2013-03-23
eventOf	[Pathway:R-HSA-3232118] SUMOylation of transcription factors - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:4162] protein sumoylation
input	[EntityWithAccessionedSequence:R-HSA-201592] MITF [nucleoplasm] 2 × [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3232149] Sumoylation of MITF and its related family members TFE3 and TFEB
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PIAS3 SUMOylates MITF with SUMO1
orthologousEvent	[Reaction:R-SCE-3232162] PIAS3 SUMOylates MITF with SUMO1 - Saccharomyces cerevisiae [Reaction:R-CEL-3232162] PIAS3 SUMOylates MITF with SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-3232162] PIAS3 SUMOylates MITF with SUMO1 - Gallus gallus [Reaction:R-DRE-3232162] PIAS3 SUMOylates MITF with SUMO1 - Danio rerio [Reaction:R-SSC-3232162] PIAS3 SUMOylates MITF with SUMO1 - Sus scrofa [Reaction:R-BTA-3232162] PIAS3 SUMOylates MITF with SUMO1 - Bos taurus [Reaction:R-RNO-3232162] PIAS3 SUMOylates MITF with SUMO1 - Rattus norvegicus [Reaction:R-MMU-3232162] PIAS3 SUMOylates MITF with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3232153] monoSUMO1-K289,423-MITF [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6804453] Fisher, David E, 2015-10-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3232162
summation	[Summation:4663729] PIAS3 SUMOylates MITF with SUMO1 at lysine-289 and lysine-42...
updateTrackers	[UpdateTracker:9775158] Update Tracker - [Reaction:3232162] PIAS3 SUMOylates MITF with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775158] Update Tracker - [Reaction:3232162] PIAS3 SUMOylates MITF with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3232118] SUMOylation of transcription factors

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