Reactome | UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1

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UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 Show undefined attributes

authored	[InstanceEdit:3927966] May, B, 2013-07-21
catalystActivity	[CatalystActivity:3968392] SUMO transferase activity of UBE2I,PIAS1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643195] SUMO transferase activity of UBE2I,PIAS1 [nucleoplasm] Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3968393] May, B, 2013-07-23
dbId	3968414
displayName	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1
edited	[InstanceEdit:3927966] May, B, 2013-07-21 [InstanceEdit:8955678] Bae, Jeehyeon, 2017-01-12 [InstanceEdit:8955680] Crisponi, Laura, 2017-01-12
eventOf	[Pathway:R-HSA-3232118] SUMOylation of transcription factors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3968421] FOXL2 [nucleoplasm] 3 × [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3968385] Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene [LiteratureReference:3968433] The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity [LiteratureReference:3968404] SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies [LiteratureReference:8953824] FOXL2 posttranslational modifications mediated by GSK3? determine the growth of granulosa cell tumours
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1
orthologousEvent	[Reaction:R-SCE-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Saccharomyces cerevisiae [Reaction:R-SPO-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Schizosaccharomyces pombe [Reaction:R-CEL-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Gallus gallus [Reaction:R-DRE-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Danio rerio [Reaction:R-SSC-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Sus scrofa [Reaction:R-BTA-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Bos taurus [Reaction:R-RNO-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3968395] monoSUMO1-K25,K114,K150-FOXL2 [nucleoplasm] 3 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8955678] Bae, Jeehyeon, 2017-01-12 [InstanceEdit:8955680] Crisponi, Laura, 2017-01-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3968414
summation	[Summation:3968430] UBC9 and PIAS1 SUMOylate FOXL2 with SUMO1 (Kuo et al. 2009, ...
updateTrackers	[UpdateTracker:9775193] Update Tracker - [Reaction:3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775193] Update Tracker - [Reaction:3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3232118] SUMOylation of transcription factors

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