Reactome | PIAS1,2-1 SUMOylate HIC1 with SUMO1

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PIAS1,2-1 SUMOylate HIC1 with SUMO1 Show undefined attributes

authored	[InstanceEdit:4086098] May, B, 2013-08-06
catalystActivity	[CatalystActivity:4090313] SUMO transferase activity of PIAS1,2-1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643459] SUMO transferase activity of PIAS1,2-1 [nucleoplasm] An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4090291] May, B, 2013-08-13
dbId	4090281
displayName	PIAS1,2-1 SUMOylate HIC1 with SUMO1
edited	[InstanceEdit:4086098] May, B, 2013-08-06 [InstanceEdit:8955684] Leprince, Dominique, 2017-01-12
eventOf	[Pathway:R-HSA-3232118] SUMOylation of transcription factors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-4090364] HIC1 [nucleoplasm] [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4090292] An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity [LiteratureReference:8953844] DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair [LiteratureReference:8955677] Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells [LiteratureReference:8955676] HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs)
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PIAS1,2-1 SUMOylate HIC1 with SUMO1
orthologousEvent	[Reaction:R-GGA-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Gallus gallus [Reaction:R-DRE-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Danio rerio [Reaction:R-SSC-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Sus scrofa [Reaction:R-BTA-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Bos taurus [Reaction:R-RNO-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4090368] monoSUMO1-K333-HIC1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8955684] Leprince, Dominique, 2017-01-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4090281
summation	[Summation:4090383] PIAS1,2-1 SUMOylate deacetylated HIC1 at lysine-333 (lysine ...
updateTrackers	[UpdateTracker:9775040] Update Tracker - [Reaction:4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775040] Update Tracker - [Reaction:4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3232118] SUMOylation of transcription factors

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