Reactome | HDMs demethylate histones

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HDMs demethylate histones Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
created	[InstanceEdit:3214866] Jupe, S, 2013-03-12
dbId	3214842
displayName	HDMs demethylate histones
doi	10.3180/r-hsa-3214842.1
edited	[InstanceEdit:5252136] Jupe, S, 2014-02-05
eventOf	[Pathway:R-HSA-3247509] Chromatin modifying enzymes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3214912] KDM1A, KDM1B demethylate MeK5-histone H3 - Homo sapiens [Reaction:R-HSA-5661123] KDM1A, KDM1B demethylate Me2K5-histone H3 - Homo sapiens [Reaction:R-HSA-4722133] KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 - Homo sapiens [Reaction:R-HSA-5661114] KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 - Homo sapiens [Reaction:R-HSA-4724284] KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 - Homo sapiens [Reaction:R-HSA-5661115] KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 - Homo sapiens [Reaction:R-HSA-4724279] KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 - Homo sapiens [Reaction:R-HSA-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Homo sapiens [Reaction:R-HSA-4754181] KDM5A-D demethylate Me2K5-histone H3 - Homo sapiens [Reaction:R-HSA-5661116] KDM5A-D demethylate Me3K5-histone H3 - Homo sapiens [Reaction:R-HSA-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Homo sapiens [Reaction:R-HSA-5661121] KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 - Homo sapiens [Reaction:R-HSA-4754176] JMJD6 demethylates MeR3-histone H3 - Homo sapiens [Reaction:R-HSA-5661122] JMJD6 demethylates Me2R3-histone H3 - Homo sapiens [Reaction:R-HSA-5661125] JMJD6 demethylates Me2sR4-HIST1H4 - Homo sapiens [Reaction:R-HSA-5661124] JMJD6 demethylates MeR4-HIST1H4 - Homo sapiens [Reaction:R-HSA-5423117] PHF8 demethylates MeK21-histone H4 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:4687090] The diverse functions of histone lysine methylation
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	HDMs demethylate histones
orthologousEvent	[Pathway:R-PFA-3214842] HDMs demethylate histones - Plasmodium falciparum [Pathway:R-SCE-3214842] HDMs demethylate histones - Saccharomyces cerevisiae [Pathway:R-SPO-3214842] HDMs demethylate histones - Schizosaccharomyces pombe [Pathway:R-CEL-3214842] HDMs demethylate histones - Caenorhabditis elegans [Pathway:R-DME-3214842] HDMs demethylate histones - Drosophila melanogaster [Pathway:R-GGA-3214842] HDMs demethylate histones - Gallus gallus [Pathway:R-XTR-3214842] HDMs demethylate histones - Xenopus tropicalis [Pathway:R-DRE-3214842] HDMs demethylate histones - Danio rerio [Pathway:R-SSC-3214842] HDMs demethylate histones - Sus scrofa [Pathway:R-BTA-3214842] HDMs demethylate histones - Bos taurus [Pathway:R-CFA-3214842] HDMs demethylate histones - Canis familiaris [Pathway:R-RNO-3214842] HDMs demethylate histones - Rattus norvegicus [Pathway:R-MMU-3214842] HDMs demethylate histones - Mus musculus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5423120] Schofield, Christopher J, 2014-05-08 [InstanceEdit:5423100] Walport, Louise, 2014-05-08 [InstanceEdit:5423113] Hopkinson, Richard, 2014-05-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3214842
summation	[Summation:3214874] Histone lysine demethylases (KDMs) are able to reverse N-met...
updateTrackers	[UpdateTracker:9785037] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v52:[addHasEvent, updateContainedRLE] [UpdateTracker:9783385] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v56:[updateContainedRLE] [UpdateTracker:9782366] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v59:[updateContainedRLE] [UpdateTracker:9784851] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v53:[addHasEvent] [UpdateTracker:9783133] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v57:[updateContainedRLE] [UpdateTracker:9778361] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v68:[updateContainedRLE] [UpdateTracker:9786133] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v50:[modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9785037] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v52:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783385] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v56:[updateContainedRLE]
[UpdateTracker:9782366] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v59:[updateContainedRLE]
[UpdateTracker:9784851] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v53:[addHasEvent]
[UpdateTracker:9783133] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v57:[updateContainedRLE]
[UpdateTracker:9778361] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v68:[updateContainedRLE]
[UpdateTracker:9786133] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v50:[modifyText]

(hasEvent)

[Pathway:R-HSA-3247509] Chromatin modifying enzymes

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