Reactome | HDMs demethylate histones

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HDMs demethylate histones Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995307
displayName	HDMs demethylate histones
eventOf	[Pathway:R-CEL-3247509] Chromatin modifying enzymes - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-3214912] KDM1A, KDM1B demethylate MeK5-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661123] KDM1A, KDM1B demethylate Me2K5-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-4722133] KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661114] KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-4724284] KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661115] KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-4724279] KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-4754181] KDM5A-D demethylate Me2K5-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661116] KDM5A-D demethylate Me3K5-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661121] KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-4754176] JMJD6 demethylates MeR3-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661122] JMJD6 demethylates Me2R3-histone H3 - Caenorhabditis elegans [Reaction:R-CEL-5661125] JMJD6 demethylates Me2sR4-HIST1H4 - Caenorhabditis elegans [Reaction:R-CEL-5661124] JMJD6 demethylates MeR4-HIST1H4 - Caenorhabditis elegans [Reaction:R-CEL-5423117] PHF8 demethylates MeK21-histone H4 - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-3214842] HDMs demethylate histones - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	HDMs demethylate histones
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-3214842
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-3247509] Chromatin modifying enzymes
(inferredTo)	[Pathway:R-HSA-3214842] HDMs demethylate histones

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