Reactome | KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3

Schema > Reaction > Entries

KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:4754168] histone demethylase activity of KDM4A, KDM4B, KDM4C, KDM4D, MINA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5661119] Jupe, Steve, 2015-01-09
dbId	5661120
displayName	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3
edited	[InstanceEdit:5252136] Jupe, S, 2014-02-05
eventOf	[Pathway:R-HSA-3214842] HDMs demethylate histones - Homo sapiens
input	[SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [CandidateSet:R-HSA-5634754] Me3K10-histone H3 [nucleoplasm] [SimpleEntity:R-ALL-113685] O2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4687058] The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 [LiteratureReference:4687069] Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells [LiteratureReference:4687044] Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases [LiteratureReference:8942430] Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3
orthologousEvent	[Reaction:R-CEL-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Caenorhabditis elegans [Reaction:R-DRE-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Danio rerio [Reaction:R-SSC-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Sus scrofa [Reaction:R-BTA-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Bos taurus [Reaction:R-CFA-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Canis familiaris [Reaction:R-RNO-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Rattus norvegicus [Reaction:R-MMU-5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - Mus musculus
output	[SimpleEntity:R-ALL-29478] CH2O [nucleoplasm] [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [CandidateSet:R-HSA-5634724] Me2K10-histone H3 [nucleoplasm] [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5423120] Schofield, Christopher J, 2014-05-08 [InstanceEdit:5423100] Walport, Louise, 2014-05-08 [InstanceEdit:5423113] Hopkinson, Richard, 2014-05-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5661120
summation	[Summation:4754179] All characterized lysine demethylases other than KDM1A belon...
updateTrackers	[UpdateTracker:9782237] Update Tracker - [Reaction:5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - v59:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782237] Update Tracker - [Reaction:5661120] KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 - v59:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-3214842] HDMs demethylate histones