Reactome | KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3

Schema > Reaction > Entries

KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:4754232] histone demethylase activity of KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4754194] Jupe, S, 2013-10-24
dbId	4754187
displayName	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3
edited	[InstanceEdit:5252136] Jupe, S, 2014-02-05
eventOf	[Pathway:R-HSA-3214842] HDMs demethylate histones - Homo sapiens
input	[SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [CandidateSet:R-HSA-5649790] Me2K28-histone H3 [nucleoplasm] [SimpleEntity:R-ALL-113685] O2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4687075] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development [LiteratureReference:5423116] Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4 [LiteratureReference:5423121] Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3
orthologousEvent	[Reaction:R-CEL-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Caenorhabditis elegans [Reaction:R-DRE-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Danio rerio [Reaction:R-SSC-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Sus scrofa [Reaction:R-BTA-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Bos taurus [Reaction:R-CFA-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Canis familiaris [Reaction:R-RNO-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Rattus norvegicus [Reaction:R-MMU-4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - Mus musculus
output	[SimpleEntity:R-ALL-29478] CH2O [nucleoplasm] [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [CandidateSet:R-HSA-5638329] MeK28-histone H3 [nucleoplasm] [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5423120] Schofield, Christopher J, 2014-05-08 [InstanceEdit:5423100] Walport, Louise, 2014-05-08 [InstanceEdit:5423113] Hopkinson, Richard, 2014-05-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4754187
summation	[Summation:4754196] All characterized lysine demethylases other than KDM1A belon...
updateTrackers	[UpdateTracker:9783731] Update Tracker - [Reaction:4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - v56:[modifyText] [UpdateTracker:9784966] Update Tracker - [Reaction:4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - v52:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9783731] Update Tracker - [Reaction:4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - v56:[modifyText] [UpdateTracker:9784966] Update Tracker - [Reaction:4754187] KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 - v52:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3214842] HDMs demethylate histones