Reactome | Phosphorylated ETS2 binds p16INK4A promoter

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Phosphorylated ETS2 binds p16INK4A promoter Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8979084] Orlic-Milacic, Marija, 2017-02-21
dbId	8979082
displayName	Phosphorylated ETS2 binds p16INK4A promoter
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3200017] CDKN2A gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3132735] p-T72-ETS2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3200021] Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated ETS2 binds p16INK4A promoter
output	[Complex:R-HSA-8979081] p-T72-ETS2:CDKN2A gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3132737] MAPKs phosphorylate ETS1 and ETS2 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8979090] Negative regulation by 'p-T72-ETS2:ID1 [nucleoplasm]'
regulationReference	[RegulationReference:9641357] Negative regulation by 'p-T72-ETS2:ID1 [nucleoplasm]' Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8979082
summation	[Summation:8979085] ETS2, activated by RAS/RAF/MAP kinase cascade, binds the pro...
updateTrackers	[UpdateTracker:9777794] Update Tracker - [Reaction:8979082] Phosphorylated ETS2 binds p16INK4A promoter - v69:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777794] Update Tracker - [Reaction:8979082] Phosphorylated ETS2 binds p16INK4A promoter - v69:[modifyText]
(hasEvent)	[Pathway:R-HSA-2559585] Oncogene Induced Senescence
(precedingEvent)	[BlackBoxEvent:R-HSA-3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA

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