p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA

Stable Identifier
R-HSA-3209098
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA
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Phosphorylated ETS1 and ETS2 stimulate p16INK4A transcription, resulting in cell cycle arrest with arrested cells exhibiting high p16INK4A level and senescence-associated beta-galactosidase activity. It is possible that ETS2 is the main transmitter of RAS signaling to p16INK4A at the initiation of the senescence program, and that ETS1 maintains high p16INK4A level once the senescence is already established (Ohtani et al. 2001).
Literature References
PubMed ID Title Journal Year
11234019 Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

Sharrocks, AD, Peters, G, Ohashi, Y, Sugimoto, M, Zebedee, Z, Ohtani, N, Huot, TJ, Hara, E, Stinson, JA

Nature 2001
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-T38-ETS1/ p-T72-ETS2:CDKN2A Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-T38-ETS1/ p-T72-ETS2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-01)
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