Reactome | SUMOylation of DNA damage response and repair proteins

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SUMOylation of DNA damage response and repair proteins Show undefined attributes

authored	[InstanceEdit:3065680] May, B, 2013-02-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3108223] May, B, 2013-02-10
dbId	3108214
displayName	SUMOylation of DNA damage response and repair proteins
edited	[InstanceEdit:3065680] May, B, 2013-02-06
eventOf	[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-4568914] SUMOylation of BLM with SUMO2,3 - Homo sapiens [Reaction:R-HSA-2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 - Homo sapiens [Reaction:R-HSA-2997616] PIAS1,4 SUMOylates BRCA1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4570463] CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-3108212] SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 - Homo sapiens [Reaction:R-HSA-4551724] PIAS4 SUMOylates HERC2 with SUMO1 - Homo sapiens [Reaction:R-HSA-4570554] SUMOylation of MDC1 with SUMO1 - Homo sapiens [Reaction:R-HSA-4570553] SUMOylation of MDC1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4551604] PIAS4 SUMOylates PARP1 with SUMO1 - Homo sapiens [Reaction:R-HSA-4551768] PIAS4 SUMOylates PARP1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-3000383] UBE2I, HDAC7 SUMOylate PML with SUMO1 - Homo sapiens [Reaction:R-HSA-5228508] RANBP2 SUMOylates PML with SUMO1 - Homo sapiens [Reaction:R-HSA-3000411] RANBP2 SUMOylates PML with SUMO2 - Homo sapiens [Reaction:R-HSA-3000433] SUMOylation of PML with SUMO3 - Homo sapiens [Reaction:R-HSA-4568863] SUMOylation of RAD52 with SUMO1 - Homo sapiens [Reaction:R-HSA-4551661] PIAS4 SUMOylates RNF168 with SUMO1 - Homo sapiens [Reaction:R-HSA-4551616] SUMOylation of RPA1 (RPA70) with SUMO2,3 - Homo sapiens [Reaction:R-HSA-3000399] RANBP2 SUMOylates SP100 with SUMO1 - Homo sapiens [Reaction:R-HSA-3000348] RANBP2 SUMOylates SP100 with SUMO2 - Homo sapiens [Reaction:R-HSA-4551648] SUMOylation of TDG with SUMO1 - Homo sapiens [Reaction:R-HSA-4551738] SUMOylation of TDG with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4568846] CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 - Homo sapiens [Reaction:R-HSA-4568848] PIAS1,2-1 SUMOylates XRCC4 with SUMO1 - Homo sapiens [Reaction:R-HSA-4570528] SUMOylation of XPC with SUMO1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:4663793] Regulation of DNA damage responses by ubiquitin and SUMO [LiteratureReference:4663772] Ubiquitin and SUMO in DNA repair at a glance [LiteratureReference:4663756] The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks [LiteratureReference:4663738] SUMOylation and de-SUMOylation in response to DNA damage [LiteratureReference:5215905] Sumoylation: a regulatory protein modification in health and disease [LiteratureReference:5225691] Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair [LiteratureReference:5225688] It takes two to tango: Ubiquitin and SUMO in the DNA damage response [LiteratureReference:5228438] Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair [LiteratureReference:5677002] Sumoylation and the DNA damage response [LiteratureReference:5676988] SUMO playing tag with ubiquitin
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SUMOylation of DNA damage response and repair proteins
orthologousEvent	[Pathway:R-MMU-3108214] SUMOylation of DNA damage response and repair proteins - Mus musculus [Pathway:R-RNO-3108214] SUMOylation of DNA damage response and repair proteins - Rattus norvegicus [Pathway:R-BTA-3108214] SUMOylation of DNA damage response and repair proteins - Bos taurus [Pathway:R-SSC-3108214] SUMOylation of DNA damage response and repair proteins - Sus scrofa [Pathway:R-DRE-3108214] SUMOylation of DNA damage response and repair proteins - Danio rerio [Pathway:R-XTR-3108214] SUMOylation of DNA damage response and repair proteins - Xenopus tropicalis [Pathway:R-GGA-3108214] SUMOylation of DNA damage response and repair proteins - Gallus gallus [Pathway:R-DME-3108214] SUMOylation of DNA damage response and repair proteins - Drosophila melanogaster [Pathway:R-CEL-3108214] SUMOylation of DNA damage response and repair proteins - Caenorhabditis elegans [Pathway:R-DDI-3108214] SUMOylation of DNA damage response and repair proteins - Dictyostelium discoideum [Pathway:R-SPO-3108214] SUMOylation of DNA damage response and repair proteins - Schizosaccharomyces pombe [Pathway:R-SCE-3108214] SUMOylation of DNA damage response and repair proteins - Saccharomyces cerevisiae [Pathway:R-PFA-3108214] SUMOylation of DNA damage response and repair proteins - Plasmodium falciparum
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3108214
summation	[Summation:5225572] Several factors that participate in DNA damage response and ...
updateTrackers	[UpdateTracker:9774898] Update Tracker - [Pathway:3108214] SUMOylation of DNA damage response and repair proteins - v80:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins
(updatedInstance)	[UpdateTracker:9774898] Update Tracker - [Pathway:3108214] SUMOylation of DNA damage response and repair proteins - v80:[updateContainedRLE]

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