Reactome | SUMOylation of DNA damage response and repair proteins

SUMOylation of DNA damage response and repair proteins

Stable Identifier

R-HSA-3108214

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SUMOylation of DNA damage response and repair proteins

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Several factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferrari 2013, Flotho and Melchior 2013, Jackson and Durocher 2013). SUMOylation can alter enzymatic activity and protein stability or it can serve to recruit additional factors. For example, SUMOylation of Thymine DNA glycosylase (TDG) causes TDG to lose affinity for its product, an abasic site opposite a G residue, and thus increases turnover of the enzyme. During repair of double-strand breaks SUMO1, SUMO2, SUMO3, and the SUMO E3 ligases PIAS1 and PIAS4 accumulate at double-strand breaks where BRCA1, HERC1, RNF168, MDC1, and TP53BP1 are SUMOylated. SUMOylation of BRCA1 may increase its ubiquitin ligase activity while SUMOylation of MDC1 and HERC2 appears to play a role in recruitment of proteins such as RNF4 and RNF8 to double strand breaks. Similarly SUMOylation of RPA1 (RPA70) recruits RAD51 in the homologous recombination pathway.

Literature References

PubMed ID	Title	Journal	Year
23122649	Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair Psakhye, I, Jentsch, S	Cell	2012
23416108	Regulation of DNA damage responses by ubiquitin and SUMO Jackson, SP, Durocher, D	Mol. Cell	2013
23781231	It takes two to tango: Ubiquitin and SUMO in the DNA damage response Bologna, S, Ferrari, S	Front Genet	2013
21896653	Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair van Wijk, SJ, Müller, S, Dikic, I	Genes Dev.	2011
22018829	SUMO playing tag with ubiquitin Praefcke, GJ, Hofmann, K, Dohmen, RJ	Trends Biochem. Sci.	2012
22357966	Ubiquitin and SUMO in DNA repair at a glance Ulrich, HD	J. Cell. Sci.	2012
21664912	The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks Bekker-Jensen, S, Mailand, N	FEBS Lett.	2011
24926426	Sumoylation and the DNA damage response Cremona, CA, Sarangi, P, Zhao, X	Biomolecules	2012
21486569	SUMOylation and de-SUMOylation in response to DNA damage Dou, H, Huang, C, Van Nguyen, T, Lu, LS, Yeh, ET	FEBS Lett.	2011
23746258	Sumoylation: a regulatory protein modification in health and disease Flotho, A, Melchior, F	Annu. Rev. Biochem.	2013