Reactome | SUMOylation of DNA damage response and repair proteins

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SUMOylation of DNA damage response and repair proteins Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050364
displayName	SUMOylation of DNA damage response and repair proteins
eventOf	[Pathway:R-DDI-3108232] SUMO E3 ligases SUMOylate target proteins - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-4568914] SUMOylation of BLM with SUMO2,3 - Dictyostelium discoideum [Reaction:R-DDI-2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 - Dictyostelium discoideum [Reaction:R-DDI-2997616] PIAS1,4 SUMOylates BRCA1 with SUMO2,3 - Dictyostelium discoideum [Reaction:R-DDI-3108212] SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 - Dictyostelium discoideum [Reaction:R-DDI-4570554] SUMOylation of MDC1 with SUMO1 - Dictyostelium discoideum [Reaction:R-DDI-4570553] SUMOylation of MDC1 with SUMO2,3 - Dictyostelium discoideum [Reaction:R-DDI-4551604] PIAS4 SUMOylates PARP1 with SUMO1 - Dictyostelium discoideum [Reaction:R-DDI-4551768] PIAS4 SUMOylates PARP1 with SUMO2,3 - Dictyostelium discoideum [Reaction:R-DDI-3000383] UBE2I, HDAC7 SUMOylate PML with SUMO1 - Dictyostelium discoideum [Reaction:R-DDI-3000433] SUMOylation of PML with SUMO3 - Dictyostelium discoideum [Reaction:R-DDI-4568863] SUMOylation of RAD52 with SUMO1 - Dictyostelium discoideum [Reaction:R-DDI-4568848] PIAS1,2-1 SUMOylates XRCC4 with SUMO1 - Dictyostelium discoideum [Reaction:R-DDI-4570528] SUMOylation of XPC with SUMO1 - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-3108214] SUMOylation of DNA damage response and repair proteins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SUMOylation of DNA damage response and repair proteins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-3108214
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-3108232] SUMO E3 ligases SUMOylate target proteins
(inferredTo)	[Pathway:R-HSA-3108214] SUMOylation of DNA damage response and repair proteins

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