Reactome | SUMOylation of BLM with SUMO2,3

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SUMOylation of BLM with SUMO2,3 Show undefined attributes

authored	[InstanceEdit:4551770] May, B, 2013-09-14
catalystActivity	[CatalystActivity:3246099] SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4568862] May, B, 2013-09-19
dbId	4568914
displayName	SUMOylation of BLM with SUMO2,3
edited	[InstanceEdit:4551770] May, B, 2013-09-14
eventOf	[Pathway:R-HSA-3108214] SUMOylation of DNA damage response and repair proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-174881] BLM [nucleoplasm] 8 × [DefinedSet:R-HSA-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4568866] Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification [LiteratureReference:4568896] Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification [LiteratureReference:4568887] SUMO modification regulates BLM and RAD51 interaction at damaged replication forks [LiteratureReference:4568865] BLM SUMOylation regulates ssDNA accumulation at stalled replication forks [LiteratureReference:5626896] Uncovering global SUMOylation signaling networks in a site-specific manner
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SUMOylation of BLM with SUMO2,3
orthologousEvent	[Reaction:R-PFA-4568914] SUMOylation of BLM with SUMO2,3 - Plasmodium falciparum [Reaction:R-DDI-4568914] SUMOylation of BLM with SUMO2,3 - Dictyostelium discoideum [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-GGA-4568914] SUMOylation of BLM with SUMO2,3 - Gallus gallus [Reaction:R-XTR-4568914] SUMOylation of BLM with SUMO2,3 - Xenopus tropicalis [Reaction:R-SSC-4568914] SUMOylation of BLM with SUMO2,3 - Sus scrofa [Reaction:R-BTA-4568914] SUMOylation of BLM with SUMO2,3 - Bos taurus [Reaction:R-RNO-4568914] SUMOylation of BLM with SUMO2,3 - Rattus norvegicus [Reaction:R-MMU-4568914] SUMOylation of BLM with SUMO2,3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4568883] 4SUMO2,3-BLM [nucleoplasm] 8 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4568914
summation	[Summation:4568895] BLM is SUMOylated at lysine-317, lysine-331, lysine-344, and...

Referrals

(hasEvent)

[Pathway:R-HSA-3108214] SUMOylation of DNA damage response and repair proteins