Reactome | RANBP2 SUMOylates PML with SUMO1

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RANBP2 SUMOylates PML with SUMO1 Show undefined attributes

authored	[InstanceEdit:2997736] May, B, 2013-01-23
catalystActivity	[CatalystActivity:3000418] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference	[CatalystActivityReference:9644133] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:5228504] May, B, 2014-01-13
dbId	5228508
displayName	RANBP2 SUMOylates PML with SUMO1
edited	[InstanceEdit:2997736] May, B, 2013-01-23
eventOf	[Pathway:R-HSA-3108214] SUMOylation of DNA damage response and repair proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1031706] PML [nucleoplasm] 3 × [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3000402] Identification of three major sentrinization sites in PML [LiteratureReference:3000394] Covalent modification of PML by the sentrin family of ubiquitin-like proteins [LiteratureReference:3000361] SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation [LiteratureReference:3000456] Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1 [LiteratureReference:3000461] Cell cycle regulation of PML modification and ND10 composition [LiteratureReference:3000459] Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection [LiteratureReference:3000377] In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies [LiteratureReference:5627528] A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RANBP2 SUMOylates PML with SUMO1
orthologousEvent	[Reaction:R-CEL-5228508] RANBP2 SUMOylates PML with SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-5228508] RANBP2 SUMOylates PML with SUMO1 - Gallus gallus [Reaction:R-SSC-5228508] RANBP2 SUMOylates PML with SUMO1 - Sus scrofa [Reaction:R-BTA-5228508] RANBP2 SUMOylates PML with SUMO1 - Bos taurus [Reaction:R-RNO-5228508] RANBP2 SUMOylates PML with SUMO1 - Rattus norvegicus [Reaction:R-MMU-5228508] RANBP2 SUMOylates PML with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3000440] monoSUMO1-K65,160,490-PML [nucleoplasm] 3 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5228508
summation	[Summation:5228527] RANBP2 of the nuclear pore complex SUMOylates PML with SUMO1...
updateTrackers	[UpdateTracker:9774992] Update Tracker - [Reaction:5228508] RANBP2 SUMOylates PML with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9774992] Update Tracker - [Reaction:5228508] RANBP2 SUMOylates PML with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3108214] SUMOylation of DNA damage response and repair proteins

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