Reactome | ECM proteoglycans

Schema > Pathway > Entries

ECM proteoglycans Show undefined attributes

authored	[InstanceEdit:2976617] Jupe, S, 2013-01-10
created	[InstanceEdit:3000161] Jupe, S, 2013-01-24
dbId	3000178
displayName	ECM proteoglycans
doi	10.3180/REACT_163906.1
edited	[InstanceEdit:3318356] Jupe, S, 2013-04-26
eventOf	[TopLevelPathway:R-HSA-1474244] Extracellular matrix organization - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20745] extracellular matrix organization
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2327886] SLRPs bind TGF Beta - Homo sapiens [Reaction:R-HSA-2327909] DCN binds collagen I, II, III, VI fibrils - Homo sapiens [Reaction:R-HSA-2466106] BGN binds Collagen types I, VI, (IX) - Homo sapiens [Reaction:R-HSA-2466238] BGN binds Collagen types II, III - Homo sapiens [Reaction:R-HSA-2465883] VTN binds collagens I, IV and VI - Homo sapiens [Reaction:R-HSA-2396370] VTN binds collagens II, III and V - Homo sapiens [Reaction:R-HSA-2426471] VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 - Homo sapiens [Reaction:R-HSA-2396079] VTN binds Plasminogen activator inhibitor- 1 - Homo sapiens [Reaction:R-HSA-2467716] AGRN binds Alpha-dystroglycan - Homo sapiens [Reaction:R-HSA-2467633] AGRN binds LRP4:MUSK - Homo sapiens [Reaction:R-HSA-2396124] AGRN binds Laminins with gamma-1 subunit - Homo sapiens [Reaction:R-HSA-2467659] AGRN binds NCAM1, PTPRS - Homo sapiens [Reaction:R-HSA-2467665] AGRN binds Beta amyloid fibril via GAG chains - Homo sapiens [Reaction:R-HSA-2424243] SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ - Homo sapiens [Reaction:R-HSA-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Homo sapiens [Reaction:R-HSA-2424246] Tenascins C, R, (X, N) bind lecticans - Homo sapiens [Reaction:R-HSA-2681681] Tenascins C, R, (X, N) bind fibronectin matrix - Homo sapiens [Reaction:R-HSA-2424252] COMP binds collagen, fibronectin, aggrecan and matrilins - Homo sapiens [Reaction:R-HSA-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Homo sapiens [Reaction:R-HSA-4086204] IBSP binds collagen type I - Homo sapiens [Reaction:R-HSA-4086200] Dentin matrix protein 1 binds integrin alphaVbeta3 - Homo sapiens [Reaction:R-HSA-4086132] Dentin phosphoprotein binds integrin alphaVbeta1 - Homo sapiens [Reaction:R-HSA-2396395] HSPG2 (perlecan) binds alpha-dystroglycan - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-12-18
literatureReference	[Book:1638021] Proteoglycans and Sulfated Glycosaminoglycans [LiteratureReference:3000185] Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor [Book:3000162] Hay, Elizabeth Cell Biology of Extracellular Matrix [Book:3597654] Hay, Elizabeth Cell Biology of Extracellular Matrix Proteoglycans: structure and function
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ECM proteoglycans
orthologousEvent	[Pathway:R-MMU-3000178] ECM proteoglycans - Mus musculus [Pathway:R-RNO-3000178] ECM proteoglycans - Rattus norvegicus [Pathway:R-CFA-3000178] ECM proteoglycans - Canis familiaris [Pathway:R-BTA-3000178] ECM proteoglycans - Bos taurus [Pathway:R-SSC-3000178] ECM proteoglycans - Sus scrofa [Pathway:R-DRE-3000178] ECM proteoglycans - Danio rerio [Pathway:R-XTR-3000178] ECM proteoglycans - Xenopus tropicalis [Pathway:R-GGA-3000178] ECM proteoglycans - Gallus gallus [Pathway:R-DME-3000178] ECM proteoglycans - Drosophila melanogaster [Pathway:R-CEL-3000178] ECM proteoglycans - Caenorhabditis elegans [Pathway:R-DDI-3000178] ECM proteoglycans - Dictyostelium discoideum
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597636] Narayanan, Venkatesan, 2013-05-21 [InstanceEdit:3597676] Ricard-Blum, Sylvie, 2013-05-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3000178
summation	[Summation:3000181] Proteoglycans are major components of the extracellular matr...
updateTrackers	[UpdateTracker:9787288] Update Tracker - [Pathway:3000178] ECM proteoglycans - v46:[addHasEvent, updateContainedRLE] [UpdateTracker:9780488] Update Tracker - [Pathway:3000178] ECM proteoglycans - v63:[addHasEvent] [UpdateTracker:9781702] Update Tracker - [Pathway:3000178] ECM proteoglycans - v60:[updateContainedRLE]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-1474244] Extracellular matrix organization
(updatedInstance)	[UpdateTracker:9787288] Update Tracker - [Pathway:3000178] ECM proteoglycans - v46:[addHasEvent, updateContainedRLE] [UpdateTracker:9780488] Update Tracker - [Pathway:3000178] ECM proteoglycans - v63:[addHasEvent] [UpdateTracker:9781702] Update Tracker - [Pathway:3000178] ECM proteoglycans - v60:[updateContainedRLE]

Cite Us!