Reactome | TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1

Schema > Reaction > Entries

TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 Show undefined attributes

authored	[InstanceEdit:2976617] Jupe, S, 2013-01-10
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2681702] Jupe, S, 2012-11-28
dbId	2681667
displayName	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1
edited	[InstanceEdit:3318356] Jupe, S, 2013-04-26
eventOf	[Pathway:R-HSA-3000178] ECM proteoglycans - Homo sapiens
input	[DefinedSet:R-HSA-2681746] Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] [Complex:R-HSA-216010] Tenascin-C hexamer [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2681749] Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins [LiteratureReference:265373] Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains [LiteratureReference:2681750] Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism [LiteratureReference:216309] The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin [LiteratureReference:3597760] Neurite outgrowth by the alternatively spliced region of human tenascin-C is mediated by neuronal alpha7beta1 integrin
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1
orthologousEvent	[Reaction:R-CEL-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Caenorhabditis elegans [Reaction:R-GGA-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Gallus gallus [Reaction:R-XTR-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Xenopus tropicalis [Reaction:R-DRE-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Danio rerio [Reaction:R-SSC-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Sus scrofa [Reaction:R-BTA-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Bos taurus [Reaction:R-CFA-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Canis familiaris [Reaction:R-RNO-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Rattus norvegicus [Reaction:R-MMU-2681667] TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 - Mus musculus
output	[Complex:R-HSA-2681748] TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597636] Narayanan, Venkatesan, 2013-05-21 [InstanceEdit:3597676] Ricard-Blum, Sylvie, 2013-05-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2681667
summation	[Summation:2681679] Tenascins are a family of 4 oligomeric extracellular glycopr...

Referrals

(hasEvent)

[Pathway:R-HSA-3000178] ECM proteoglycans

Cite Us!