Reactome | MMACHC [cytosol]

Schema > EntityWithAccessionedSequence > Entries

MMACHC [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:3149491] cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity of MMACHC [cytosol] [CatalystActivity:3245899] transferase activity, transferring alkyl or aryl (other than methyl) groups of MMACHC [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9759561] MMACHC:cob(I)alamin [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-3095889] MMACHC dealkylates RCbl - Homo sapiens [Reaction:R-HSA-3149519] MMACHC decyanates CNCbl - Homo sapiens [Reaction:R-HSA-3149519] MMACHC decyanates CNCbl - Homo sapiens
created	[InstanceEdit:2980989] Jassal, B, 2013-01-14
dbId	2980949
displayName	MMACHC [cytosol]
endCoordinate	282
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-2980949] MMACHC [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-2980949] Mmachc [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-2980949] MMACHC [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-2980949] MMACHC [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-2980949] MMACHC [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-2980949] MMACHC [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-2980949] mmachc [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-2980949] MMACHC [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-CEL-2980949] MMACHC [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-2980949] MMACHC [cytosol] - Dictyostelium discoideum
maxDepth	1
modified	[InstanceEdit:3448660] Wu, G, 2013-05-16
name	MMACHC Methylmalonic aciduria and homocystinuria type C protein MMAC_HUMAN
producedByEvent	[BlackBoxEvent:R-HSA-3204318] cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR - Homo sapiens [Reaction:R-HSA-3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q9Y4U1] UniProt:Q9Y4U1 MMACHC
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2980949
startCoordinate	1

Referrals

(normalEntity)	[EntityFunctionalStatus:3318598] loss_of_function of MMACHC mutants [cytosol]
(input)	[Reaction:R-HSA-3149519] MMACHC decyanates CNCbl [Reaction:R-HSA-3095889] MMACHC dealkylates RCbl
(physicalEntity)	[CatalystActivity:3149491] cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity of MMACHC [cytosol] [CatalystActivity:3245899] transferase activity, transferring alkyl or aryl (other than methyl) groups of MMACHC [cytosol]
(output)	[BlackBoxEvent:R-HSA-3204318] cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR [Reaction:R-HSA-3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria
(hasComponent)	[Complex:R-HSA-9759561] MMACHC:cob(I)alamin [cytosol] [Complex:R-HSA-3095903] MMACHC:cob(II)alamin [cytosol]