Reactome | MMACHC decyanates CNCbl

Schema > Reaction > Entries

MMACHC decyanates CNCbl Show undefined attributes

authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:3149491] cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity of MMACHC [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
crossReference	[DatabaseIdentifier:9908088] RHEA:16115
dbId	3149519
diseaseReaction	[FailedReaction:R-HSA-3318590] Defective MMACHC does not decyanate CNCbl - Homo sapiens
displayName	MMACHC decyanates CNCbl
edited	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
eventOf	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-3149494] MMACHC:cob(II)alamin binds MMADHC - Homo sapiens
input	2 × [SimpleEntity:R-ALL-3149505] CNCbl [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-2980949] MMACHC [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3149499] Decyanation of vitamin B12 by a trafficking chaperone [LiteratureReference:9759557] Structural basis of multifunctionality in a vitamin B12-processing enzyme [LiteratureReference:3245894] Vitamin B12: unique metalorganic compounds and the most complex vitamins
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MMACHC decyanates CNCbl MMACHC reductively decyanates CNCbl 2 apo--(cyanocobalamin reductase) + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin--(cyanocobalamin reductase) + 2 hydrogen cyanide + NADP(+)
negativePrecedingEvent	[NegativePrecedingEvent:9764879] Incorrect Order: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria [NegativePrecedingEvent:9764874] Incorrect Order: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR
orthologousEvent	[Reaction:R-MMU-3149519] MMACHC decyanates CNCbl - Mus musculus [Reaction:R-DDI-3149519] MMACHC decyanates CNCbl - Dictyostelium discoideum [Reaction:R-CEL-3149519] MMACHC decyanates CNCbl - Caenorhabditis elegans [Reaction:R-GGA-3149519] MMACHC decyanates CNCbl - Gallus gallus [Reaction:R-XTR-3149519] MMACHC decyanates CNCbl - Xenopus tropicalis [Reaction:R-DRE-3149519] MMACHC decyanates CNCbl - Danio rerio [Reaction:R-SSC-3149519] MMACHC decyanates CNCbl - Sus scrofa [Reaction:R-BTA-3149519] MMACHC decyanates CNCbl - Bos taurus [Reaction:R-CFA-3149519] MMACHC decyanates CNCbl - Canis familiaris [Reaction:R-RNO-3149519] MMACHC decyanates CNCbl - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-1130611] HCN [cytosol] 2 × [Complex:R-HSA-3095903] MMACHC:cob(II)alamin [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-9759206] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3149519
summation	[Summation:3149511] Cyanocobalamin (CNCbl), a semisynthetic molecule produced fr...
updateTrackers	[UpdateTracker:9774984] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v80:[addLiteratureReference, modifyText] [UpdateTracker:9787110] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v46:[modifyText] [UpdateTracker:9786303] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9774984] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v80:[addLiteratureReference, modifyText] [UpdateTracker:9787110] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v46:[modifyText] [UpdateTracker:9786303] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v50:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-3318590] Defective MMACHC does not decyanate CNCbl
(hasEvent)	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[Reaction:R-HSA-3149494] MMACHC:cob(II)alamin binds MMADHC