Reactome | Leptin Binds Leptin Receptor

Schema > Reaction > Entries

Leptin Binds Leptin Receptor Show undefined attributes

authored	[InstanceEdit:2586547] May, B, 2012-11-15
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2586547] May, B, 2012-11-15
dbId	2586559
displayName	Leptin Binds Leptin Receptor
edited	[InstanceEdit:2671737] May, B, 2012-11-24
eventOf	[Pathway:R-HSA-2586552] Signaling by Leptin - Homo sapiens
followingEvent	[Reaction:R-HSA-2586555] JAK2 Autophosphorylates in Response to Leptin - Homo sapiens
inferredFrom	[Reaction:R-MMU-2586558] Leptin Binds Leptin Receptor - Mus musculus
input	2 × [EntityWithAccessionedSequence:R-HSA-400490] LEP [extracellular region] [Complex:R-HSA-2586523] LEPR:JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2586462] BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry [LiteratureReference:2586487] Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers [LiteratureReference:2586468] Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin [LiteratureReference:4789048] Homology modeling of human leptin/leptin receptor complex [LiteratureReference:4789059] A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Leptin Binds Leptin Receptor LEP Binds LEPR:JAK2
output	[Complex:R-HSA-2586512] LEP:LEPR:JAK2 [plasma membrane]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2586559
summation	[Summation:2672266] Analysis of a structural model of the Leptin-LEPR complex us...
updateTrackers	[UpdateTracker:9786920] Update Tracker - [Reaction:2586559] Leptin Binds Leptin Receptor - v47:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786920] Update Tracker - [Reaction:2586559] Leptin Binds Leptin Receptor - v47:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2586552] Signaling by Leptin
(precedingEvent)	[Reaction:R-HSA-2586555] JAK2 Autophosphorylates in Response to Leptin
(inferredTo)	[Reaction:R-MMU-2586558] Leptin Binds Leptin Receptor