Reactome | Leptin Binds Leptin Receptor

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Leptin Binds Leptin Receptor Show undefined attributes

authored	[InstanceEdit:2586547] May, B, 2012-11-15
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2586547] May, B, 2012-11-15
dbId	2586558
deleted	[Deleted:9032439] Deletion of instance: 2586551 [Deleted:9032440] Deletion of instance: 5334727
displayName	Leptin Binds Leptin Receptor
edited	[InstanceEdit:2671737] May, B, 2012-11-24
followingEvent	[Reaction:R-MMU-2586548] Jak2 Autophosphorylates in Response to Leptin - Mus musculus
input	[Complex:R-MMU-2586533] Lepr:Jak2 [plasma membrane] 2 × [EntityWithAccessionedSequence:R-MMU-2586529] Leptin [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2586483] The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line [LiteratureReference:2586505] Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding [LiteratureReference:2586462] BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry [LiteratureReference:2586479] Identification and expression cloning of a leptin receptor, OB-R [LiteratureReference:2586445] The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Leptin Binds Leptin Receptor Lep Binds Lepr:Jak2
orthologousEvent	[Reaction:R-HSA-2586559] Leptin Binds Leptin Receptor - Homo sapiens
output	[Complex:R-MMU-2586532] Lep:Lepr:Jak2 [plasma membrane]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2586558
summation	[Summation:2672305] Leptin binds the Leptin receptor, a transmembrane receptor t...
updateTrackers	[UpdateTracker:9786931] Update Tracker - [Reaction:2586558] Leptin Binds Leptin Receptor - v47:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786931] Update Tracker - [Reaction:2586558] Leptin Binds Leptin Receptor - v47:[modifyText]
(replacementInstances)	[Deleted:9032439] Deletion of instance: 2586551 [Deleted:9032440] Deletion of instance: 5334727
(precedingEvent)	[Reaction:R-MMU-2586548] Jak2 Autophosphorylates in Response to Leptin

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