Leptin Binds Leptin Receptor

Stable Identifier
R-HSA-2586559
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Synonyms
LEP Binds LEPR:JAK2
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Leptin Binds Leptin Receptor
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Analysis of a structural model of the Leptin-LEPR complex using as a basis the complex formed by granulocyte-colony stimulator factor (GCSF) and its receptor G-CSF R (Hiroike et al., 2000) suggested that helices I and III of the human leptin structure were likely sites of interaction with the cytokine binding domain of leptin receptor (Gonzalez and Leavis, 2003). It is believed that the Leptin receptor (LEPR) is a dimer constitutively bound in a complex with JAK2 kinase (Couturier and Jockers 2003). It has been proposed that one molecule of Leptin binds each monomer of LEPR (Luoh et al. 1997, Mistrik et al. 2004), however these suggestions need further proof becasue the structure of the Leptin:LEPR complex has not yet been solved.
Literature References
PubMed ID Title Journal Year
12897384 A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells

Leavis, PC, Gonzalez, RR

Endocrine 2003
15051545 BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry

Moreau, F, Mistrík, P, Allen, JM

Anal. Biochem. 2004
9061609 Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin

Luoh, SM, Spencer, SA, Williams, M, de Sauvage, FJ, Nelson, C, Bennett, GL, Xie, MH, Gurney, A, Levin, N, Di Marco, F, Armanini, M

J. Mol. Endocrinol. 1997
10944457 Homology modeling of human leptin/leptin receptor complex

Toh, H, Hiroike, T, Jingami, H, Higo, J

Biochem. Biophys. Res. Commun. 2000
12734179 Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers

Jockers, R, Couturier, C

J. Biol. Chem. 2003
Participants
Input
Output
Participates
as an event of
Inferred From
Leptin Binds Leptin Receptor (Mus musculus)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-15)
Cite Us!