Leptin Binds Leptin Receptor

Stable Identifier
Reaction [binding]
Homo sapiens
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Analysis of a structural model of the Leptin-LEPR complex using as a basis the complex formed by granulocyte-colony stimulator factor (GCSF) and its receptor G-CSF R (Hiroike et al., 2000) suggested that helices I and III of the human leptin structure were likely sites of interaction with the cytokine binding domain of leptin receptor (Gonzalez and Leavis, 2003). It is believed that the Leptin receptor (LEPR) is a dimer constitutively bound in a complex with JAK2 kinase (Couturier and Jockers 2003). It has been proposed that one molecule of Leptin binds each monomer of LEPR (Luoh et al. 1997, Mistrik et al. 2004), however these suggestions need further proof becasue the structure of the Leptin:LEPR complex has not yet been solved.
Literature References
PubMed ID Title Journal Year
12897384 A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells

Leavis, PC, Gonzalez, RR

Endocrine 2003
15051545 BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry

Moreau, F, MistrĂ­k, P, Allen, JM

Anal. Biochem. 2004
9061609 Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin

Luoh, SM, Spencer, SA, Williams, M, de Sauvage, FJ, Nelson, C, Bennett, GL, Xie, MH, Gurney, A, Levin, N, Di Marco, F, Armanini, M

J. Mol. Endocrinol. 1997
10944457 Homology modeling of human leptin/leptin receptor complex

Toh, H, Hiroike, T, Jingami, H, Higo, J

Biochem. Biophys. Res. Commun. 2000
12734179 Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers

Jockers, R, Couturier, C

J. Biol. Chem. 2003
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