Reactome | JAK2 Autophosphorylates in Response to Leptin

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JAK2 Autophosphorylates in Response to Leptin Show undefined attributes

authored	[InstanceEdit:2586547] May, B, 2012-11-15
catalystActivity	[CatalystActivity:2586550] protein tyrosine kinase activity of LEP:LEPR:JAK2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2586547] May, B, 2012-11-15
dbId	2586555
displayName	JAK2 Autophosphorylates in Response to Leptin
edited	[InstanceEdit:2671737] May, B, 2012-11-24
eventOf	[Pathway:R-HSA-2586552] Signaling by Leptin - Homo sapiens
followingEvent	[Reaction:R-HSA-2586553] JAK2 Phosphorylates LEPR - Homo sapiens
inferredFrom	[Reaction:R-MMU-2586548] Jak2 Autophosphorylates in Response to Leptin - Mus musculus
input	24 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2586512] LEP:LEPR:JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4420064] The role of SOCS-3 in leptin signaling and leptin resistance
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 Autophosphorylates in Response to Leptin
output	24 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2586521] LEP:LEPR:p-JAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2586559] Leptin Binds Leptin Receptor - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-4420081] Negative regulation by 'LEP:p-LEPR:p-JAK2:SOCS3 [plasma membrane]'
regulationReference	[RegulationReference:9641585] Negative regulation by 'LEP:p-LEPR:p-JAK2:SOCS3 [plasma membrane]' SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2586555
summation	[Summation:2672258] As inferred from mouse, binding of Leptin (LEP) to the Lepti... [Summation:4420080] As inferred from mouse, the kinase inhibitory domain of SOCS...
updateTrackers	[UpdateTracker:9786863] Update Tracker - [Reaction:2586555] JAK2 Autophosphorylates in Response to Leptin - v47:[modifyText] [UpdateTracker:9775916] Update Tracker - [Reaction:2586555] JAK2 Autophosphorylates in Response to Leptin - v78:[addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9786863] Update Tracker - [Reaction:2586555] JAK2 Autophosphorylates in Response to Leptin - v47:[modifyText] [UpdateTracker:9775916] Update Tracker - [Reaction:2586555] JAK2 Autophosphorylates in Response to Leptin - v78:[addSummation]
(hasEvent)	[Pathway:R-HSA-2586552] Signaling by Leptin
(precedingEvent)	[Reaction:R-HSA-2586553] JAK2 Phosphorylates LEPR
(inferredTo)	[Reaction:R-MMU-2586548] Jak2 Autophosphorylates in Response to Leptin

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