Reactome | Signaling by Leptin

Schema > Pathway > Entries

Signaling by Leptin Show undefined attributes

authored	[InstanceEdit:2586547] May, B, 2012-11-15
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2586547] May, B, 2012-11-15
crossReference	[DatabaseIdentifier:12819653] BioModels Database:BIOMD0000001077 [DatabaseIdentifier:12819655] BioModels Database:BIOMD0000000314 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313
dbId	2586552
displayName	Signaling by Leptin
doi	10.3180/REACT_169118.1
edited	[InstanceEdit:2671764] May, B, 2012-11-24
eventOf	[TopLevelPathway:R-HSA-162582] Signal Transduction - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2586559] Leptin Binds Leptin Receptor - Homo sapiens [Reaction:R-HSA-2586555] JAK2 Autophosphorylates in Response to Leptin - Homo sapiens [Reaction:R-HSA-2586553] JAK2 Phosphorylates LEPR - Homo sapiens [Reaction:R-HSA-2671747] Phosphorylated LEPR Binds SHP2 (PTPN11) - Homo sapiens [Reaction:R-HSA-2671742] JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin - Homo sapiens [Reaction:R-HSA-2671855] Phosphorylated LEPR Binds STAT5 - Homo sapiens [Reaction:R-HSA-2671829] JAK2 Phosphorylates STAT5 in Response to Leptin - Homo sapiens [Reaction:R-HSA-2671876] Phosphorylated STAT5 Dissociates from Leptin Receptor - Homo sapiens [Reaction:R-HSA-452102] p-STAT5 dimerizes - Homo sapiens [BlackBoxEvent:R-HSA-507937] STAT5 dimers translocate to the nucleus - Homo sapiens [Reaction:R-HSA-2671868] Phosphorylated LEPR Binds STAT3 - Homo sapiens [Reaction:R-HSA-2671850] JAK2 Phosphoryates STAT3 in Response to Leptin - Homo sapiens [Reaction:R-HSA-2671839] Phosphorylated STAT3 Dissociates from Leptin Receptor - Homo sapiens [Reaction:R-HSA-2730595] Phosphorylated STAT3 Forms Dimers - Homo sapiens [BlackBoxEvent:R-HSA-2730599] Phosphorylated STAT3 Dimer Translocates to the Nucleus - Homo sapiens [Reaction:R-HSA-2671872] Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 - Homo sapiens [Reaction:R-HSA-2671873] Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 - Homo sapiens [Reaction:R-HSA-2671862] JAK2 Phosphorylates IRS in Response to Leptin - Homo sapiens [Reaction:R-HSA-2672302] Phosphorylated LEPR Binds SOCS3 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:2730642] Leptin receptor signaling: pathways to leptin resistance [LiteratureReference:2730643] Leptin in human physiology and therapeutics [LiteratureReference:2730630] Central leptin receptor action and resistance in obesity [LiteratureReference:2730633] Mechanisms of leptin action and leptin resistance [LiteratureReference:2730645] Recent advances in understanding leptin signaling and leptin resistance [LiteratureReference:3270574] The role of adipokines in beta-cell failure of type 2 diabetes [LiteratureReference:3270578] Leptin receptors [LiteratureReference:3270576] Evolution of leptin structure and function [LiteratureReference:3318516] The role of leptin in the control of insulin-glucose axis [LiteratureReference:3318527] Leptin therapy, insulin sensitivity, and glucose homeostasis [LiteratureReference:3318520] Leptin and the central nervous system control of glucose metabolism [LiteratureReference:3318519] Proinflammatory activities of leptin in non-autoimmune conditions [LiteratureReference:3508841] Role of leptin in the pancreatic ?-cell: effects and signaling pathways [LiteratureReference:3508870] Obesity, leptin, and Alzheimer's disease [LiteratureReference:3508838] Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism [LiteratureReference:3508832] Central insulin and leptin-mediated autonomic control of glucose homeostasis [LiteratureReference:3508859] Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain [LiteratureReference:3508828] Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin [LiteratureReference:4420062] Leptin receptors [LiteratureReference:4789065] Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells [LiteratureReference:4789066] Leptin and Inflammation [LiteratureReference:4789053] Leptin-cytokine crosstalk in breast cancer
maxDepth	2
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	Signaling by Leptin
releaseDate	2013-09-18
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2586552
summation	[Summation:2730635] Leptin (LEP, OB, OBS), a circulating adipokine, and its rece...
updateTrackers	[UpdateTracker:9784833] Update Tracker - [Pathway:2586552] Signaling by Leptin - v53:[add_removeHasEvent] [UpdateTracker:9779137] Update Tracker - [Pathway:2586552] Signaling by Leptin - v66:[updateContainedRLE] [UpdateTracker:9781245] Update Tracker - [Pathway:2586552] Signaling by Leptin - v61:[updateContainedRLE] [UpdateTracker:9780672] Update Tracker - [Pathway:2586552] Signaling by Leptin - v62:[removeHasEvent] [UpdateTracker:9786917] Update Tracker - [Pathway:2586552] Signaling by Leptin - v47:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9783514] Update Tracker - [Pathway:2586552] Signaling by Leptin - v56:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9780400] Update Tracker - [Pathway:2586552] Signaling by Leptin - v63:[updateContainedRLE] [UpdateTracker:9776050] Update Tracker - [Pathway:2586552] Signaling by Leptin - v78:[updateContainedRLE]

Referrals

(hasEvent)

[TopLevelPathway:R-HSA-162582] Signal Transduction

(updatedInstance)

[UpdateTracker:9784833] Update Tracker - [Pathway:2586552] Signaling by Leptin - v53:[add_removeHasEvent]
[UpdateTracker:9779137] Update Tracker - [Pathway:2586552] Signaling by Leptin - v66:[updateContainedRLE]
[UpdateTracker:9781245] Update Tracker - [Pathway:2586552] Signaling by Leptin - v61:[updateContainedRLE]
[UpdateTracker:9780672] Update Tracker - [Pathway:2586552] Signaling by Leptin - v62:[removeHasEvent]
[UpdateTracker:9786917] Update Tracker - [Pathway:2586552] Signaling by Leptin - v47:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9783514] Update Tracker - [Pathway:2586552] Signaling by Leptin - v56:[updateContainedPathway, updateContainedRLE]
[UpdateTracker:9780400] Update Tracker - [Pathway:2586552] Signaling by Leptin - v63:[updateContainedRLE]
[UpdateTracker:9776050] Update Tracker - [Pathway:2586552] Signaling by Leptin - v78:[updateContainedRLE]

Cite Us!