JAK2 Autophosphorylates in Response to Leptin

Stable Identifier
R-HSA-2586555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from mouse, binding of Leptin (LEP) to the Leptin receptor (LEPR) causes a conformational change in LEPR that activates autophosphorylation of JAK2 at multiple tyrosine residues. Phosphorylated JAK2 has much higher kinase activity than unphosphorylated JAK2.

Literature References
PubMed ID Title Journal Year
10514492 The role of SOCS-3 in leptin signaling and leptin resistance

Bjørbaek, C, El-Haschimi, K, Frantz, JD, Flier, JS

J. Biol. Chem. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LEP:LEPR:JAK2 [plasma membrane]
Physical Entity
Activity
This event is regulated
Inferred From
Authored
Reviewed
Created