SeO3(2-) is reduced to H2Se by TXNRD1

Stable Identifier
R-HSA-2408558
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SeO3(2-) is reduced to H2Se by TXNRD1
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Thioredoxin reductase 1 (TXNRD1) homodimer (Sun et al. 1999) is involved in the reduction of selenite (SeO3(2-)) into hydrogen selenide (H2Se). This reaction is inferred from the event in cow (Kumar et al. 1992).
Literature References
PubMed ID Title Journal Year
1321713 Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen

Björnstedt, M, Holmgren, A, Kumar, S

Eur. J. Biochem. 1992
10455115 Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases

Jeang, KT, Zappacosta, F, Wu, Y, Sun, QA, Hatfield, DL, Lee, BJ, Gladyshev, VN

J. Biol. Chem. 1999
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Catalyst Activity

selenite reductase (NADPH) activity of TNXRD1:FAD dimer [cytosol]

Physical Entity
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
Activity
selenite reductase (NADPH) activity (GO:0098623)
Inferred From
SeO3(2-) is reduced to H2Se by TXNRD1 (Bos taurus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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