SeO3(2-) is reduced to H2Se by TXNRD1

Stable Identifier
R-HSA-2408558
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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SeO3(2-) is reduced to H2Se by TXNRD1
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Thioredoxin reductase 1 (TXNRD1) homodimer (Sun et al. 1999) is involved in the reduction of selenite (SeO3(2-)) into hydrogen selenide (H2Se). This reaction is inferred from the event in cow (Kumar et al. 1992).

Literature References
PubMed ID Title Journal Year
10455115 Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases

Sun, QA, Wu, Y, Zappacosta, F, Jeang, KT, Lee, BJ, Hatfield, DL, Gladyshev, VN

J. Biol. Chem. 1999
1321713 Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen

Kumar, S, Björnstedt, M, Holmgren, A

Eur. J. Biochem. 1992
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
selenite reductase activity of TNXRD1:FAD dimer [cytosol]
Physical Entity
TNXRD1:FAD dimer [cytosol]
Activity
selenite reductase activity (0098623)
Inferred From
SeO3(2-) is reduced to H2Se by TXNRD1 (Bos taurus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)