SeO3(2-) is reduced to H2Se by TXNRD1

Stable Identifier
R-HSA-2408558
Type
Reaction
Species
Homo sapiens
Compartment
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Thioredoxin reductase 1 (TXNRD1) homodimer (Sun et al. 1999) is involved in the reduction of selenite (SeO3(2-)) into hydrogen selenide (H2Se). This reaction is inferred from the event in cow (Kumar et al. 1992).

Literature References
PubMed ID Title Journal Year
1321713 Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen

Björnstedt, M, Holmgren, A, Kumar, S

Eur. J. Biochem. 1992
10455115 Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases

Jeang, KT, Zappacosta, F, Wu, Y, Sun, QA, Hatfield, DL, Lee, BJ, Gladyshev, VN

J. Biol. Chem. 1999
Participants
Participates
Catalyst Activity

selenite reductase activity of TNXRD1:FAD dimer [cytosol]

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