Reactome | H2Se is methylated to MeSeH by H2Se methyltransferase

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H2Se is methylated to MeSeH by H2Se methyltransferase Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359071] hydrogen selenide methyltransferase activity of HSeMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
dbId	2408536
displayName	H2Se is methylated to MeSeH by H2Se methyltransferase
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Homo sapiens
followingEvent	[Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase - Homo sapiens [Reaction:R-HSA-2408541] MeSeH is methylated to Me2Se by MeSeH methyltransferase - Homo sapiens
inferredFrom	[Reaction:R-RNO-2408511] H2Se is methylated to MeSeH by H2Se methyltransferase - Rattus norvegicus
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-5357660] selanide [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5359231] Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium [LiteratureReference:5359234] Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	H2Se is methylated to MeSeH by H2Se methyltransferase
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-5357669] MeSeH [cytosol]
precedingEvent	[Reaction:R-HSA-2408524] Sec is reduced to H2Se by PXLP-K259-SCLY dimer - Homo sapiens [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase - Homo sapiens [Reaction:R-HSA-2408558] SeO3(2-) is reduced to H2Se by TXNRD1 - Homo sapiens [Reaction:R-HSA-2408500] GSSeH condenses with GSH to form H2Se and GSSG - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2408536
summation	[Summation:5422920] A yet to be identified enzyme with hydrogen selenide methylt...

Referrals

(precedingEvent)	[Reaction:R-HSA-2408541] MeSeH is methylated to Me2Se by MeSeH methyltransferase [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase
(hasEvent)	[Pathway:R-HSA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se
(inferredTo)	[Reaction:R-RNO-2408511] H2Se is methylated to MeSeH by H2Se methyltransferase

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