Reactome | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se

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Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
dbId	2408550
displayName	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408522] Selenoamino acid metabolism - Homo sapiens
followingEvent	[Pathway:R-HSA-2408499] Formation of selenosugars for excretion - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:162304] selenium compound metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2408525] H2SeO4 is converted to APSe by PAPSS1,2 - Homo sapiens [Reaction:R-HSA-2408540] APSe is phosphorylated to PAPSe by PAPSS1,2 - Homo sapiens [Reaction:R-HSA-2408548] PAPSe is reduced to SeO3(2-) by PAPSe reductase - Homo sapiens [Reaction:R-HSA-2408558] SeO3(2-) is reduced to H2Se by TXNRD1 - Homo sapiens [Reaction:R-HSA-2408556] SeO3(2-) combines with GSH to form GSSeSG and GSSG - Homo sapiens [Reaction:R-HSA-2408542] GSSeSG is reduced to GSSeH and GSH by GSR - Homo sapiens [Reaction:R-HSA-2408500] GSSeH condenses with GSH to form H2Se and GSSG - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359348] Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2408550
summation	[Summation:5359409] Ingested selenic acid (H2SeO4) and selenite (SeO3(2-)) are r...

Referrals

(precedingEvent)	[Pathway:R-HSA-2408499] Formation of selenosugars for excretion
(hasEvent)	[Pathway:R-HSA-2408522] Selenoamino acid metabolism

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