Reactome | Metabolism of ingested SeMet, Sec, MeSec into H2Se

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Metabolism of ingested SeMet, Sec, MeSec into H2Se Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
dbId	2408508
displayName	Metabolism of ingested SeMet, Sec, MeSec into H2Se
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408522] Selenoamino acid metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:162304] selenium compound metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2408537] Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH - Homo sapiens [Reaction:R-HSA-2408551] SeMet is converted to AdoSeMet by MAT - Homo sapiens [Reaction:R-HSA-2408544] AdoSeMet is converted to AdeSeHCys by MetTrans(1) - Homo sapiens [Reaction:R-HSA-2408532] AdeSeHCys is hydrolysed to SeHCys by AHCY - Homo sapiens [Reaction:R-HSA-2408559] SeHCys and Ser are dehydrated into SeCysta by CBS - Homo sapiens [Reaction:R-HSA-2408543] SeCysta is hydrolysed to Sec by PXLP-K212-CTH - Homo sapiens [Reaction:R-HSA-2408524] Sec is reduced to H2Se by PXLP-K259-SCLY dimer - Homo sapiens [Reaction:R-HSA-2408539] MeSec is hydrolysed to MeSeH by PXLP-K212-CTH - Homo sapiens [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase - Homo sapiens [Reaction:R-HSA-2408536] H2Se is methylated to MeSeH by H2Se methyltransferase - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359208] Enzymatic synthesis of selenocysteine in rat liver [LiteratureReference:5359220] Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Metabolism of ingested SeMet, Sec, MeSec into H2Se
orthologousEvent	[Pathway:R-RNO-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Rattus norvegicus [Pathway:R-PFA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Plasmodium falciparum [Pathway:R-SCE-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Saccharomyces cerevisiae [Pathway:R-SPO-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Schizosaccharomyces pombe [Pathway:R-DDI-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Dictyostelium discoideum [Pathway:R-CEL-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Caenorhabditis elegans [Pathway:R-DME-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Drosophila melanogaster [Pathway:R-GGA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Gallus gallus [Pathway:R-XTR-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Xenopus tropicalis [Pathway:R-DRE-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Danio rerio [Pathway:R-SSC-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Sus scrofa [Pathway:R-BTA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Bos taurus [Pathway:R-CFA-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Canis familiaris [Pathway:R-MMU-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2408508
summation	[Summation:5359411] Inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and o...

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[Pathway:R-HSA-2408522] Selenoamino acid metabolism

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