H2Se is methylated to MeSeH by H2Se methyltransferase

Stable Identifier
R-HSA-2408536
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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H2Se is methylated to MeSeH by H2Se methyltransferase
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A yet to be identified enzyme with hydrogen selenide methyltransferase (HSeMT) activity is involved in the methylation of hydrogen selenide (H2Se) into methylselenol aka methaneselenol (MeSeH) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy). This reaction is inferred from the event in rat (Ohta and Suzuki 2008, Hsieh and Ganther 1977).
Literature References
PubMed ID Title Journal Year
17988700 Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Suzuki, KT, Ohta, Y

Toxicol. Appl. Pharmacol. 2008
14705 Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems

Ganther, HE, Hsieh, HS

Biochim. Biophys. Acta 1977
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Catalyst Activity

hydrogen selenide methyltransferase activity of HSeMT [cytosol]

Physical Entity
HSeMT [cytosol] (Homo sapiens)
Activity
hydrogen selenide methyltransferase activity (GO:0098614)
Inferred From
H2Se is methylated to MeSeH by H2Se methyltransferase (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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