Reactome | Metabolism of ingested SeMet, Sec, MeSec into H2Se

Metabolism of ingested SeMet, Sec, MeSec into H2Se

Stable Identifier

R-HSA-2408508

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Metabolism of ingested SeMet, Sec, MeSec into H2Se

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Inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) through the trans-selenation pathway, selenocysteine lyase (SCLY), and cystathionine gamma-lyase (CTH).

Literature References

PubMed ID	Title	Journal	Year
6456763	Enzymatic synthesis of selenocysteine in rat liver Esaki, N, Nakamura, T, Morino, Y, Soda, K, Tanaka, H, Suzuki, T	Biochemistry	1981
20383543	Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds Cooper, AJ, Sinha, R, Lee, JI, Pinto, JT, MacEwan, ME	Amino Acids	2011