Metabolism of ingested SeMet, Sec, MeSec into H2Se

Stable Identifier
R-HSA-2408508
Type
Pathway
Species
Homo sapiens
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Metabolism of ingested SeMet, Sec, MeSec into H2Se
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Inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) through the trans-selenation pathway, selenocysteine lyase (SCLY), and cystathionine gamma-lyase (CTH).

Literature References
PubMed ID Title Journal Year
20383543 Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds

Pinto, JT, Lee, JI, Sinha, R, MacEwan, ME, Cooper, AJ

Amino Acids 2011
6456763 Enzymatic synthesis of selenocysteine in rat liver

Esaki, N, Nakamura, T, Tanaka, H, Suzuki, T, Morino, Y, Soda, K

Biochemistry 1981
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Events
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Event Information
Go Biological Process
selenium compound metabolic process (0001887)
Orthologous Events
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Bos taurus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Caenorhabditis elegans)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Canis familiaris)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Danio rerio)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Dictyostelium discoideum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Drosophila melanogaster)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Gallus gallus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Mus musculus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Plasmodium falciparum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Rattus norvegicus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Saccharomyces cerevisiae)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Schizosaccharomyces pombe)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Sus scrofa)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Xenopus tropicalis)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)