Reactome | M6PR transports activated ARSA to the lysosome

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M6PR transports activated ARSA to the lysosome Show undefined attributes

authored	[InstanceEdit:2248890] Jassal, B, 2012-05-15
catalystActivity	[CatalystActivity:9841177] cargo receptor activity of M6PR [transport vesicle]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:161320] lysosomal lumen
created	[InstanceEdit:2248890] Jassal, B, 2012-05-15
dbId	2248891
displayName	M6PR transports activated ARSA to the lysosome
edited	[InstanceEdit:2248890] Jassal, B, 2012-05-15
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide - Homo sapiens [Reaction:R-HSA-9840949] ARSA removes sulfate from SM3 - Homo sapiens
input	[Complex:R-HSA-1614355] active ARSA:Ca2+ [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9841171] Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes [LiteratureReference:9841185] In vitro mutagenesis of potential N-glycosylation sites of arylsulfatase A. Effects on glycosylation, phosphorylation, and intracellular sorting
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	M6PR transports activated ARSA to the lysosome
orthologousEvent	[Reaction:R-MMU-2248891] M6PR transports activated ARSA to the lysosome - Mus musculus [Reaction:R-SPO-2248891] M6PR transports activated ARSA to the lysosome - Schizosaccharomyces pombe [Reaction:R-GGA-2248891] M6PR transports activated ARSA to the lysosome - Gallus gallus [Reaction:R-XTR-2248891] M6PR transports activated ARSA to the lysosome - Xenopus tropicalis [Reaction:R-SSC-2248891] M6PR transports activated ARSA to the lysosome - Sus scrofa [Reaction:R-BTA-2248891] M6PR transports activated ARSA to the lysosome - Bos taurus [Reaction:R-CFA-2248891] M6PR transports activated ARSA to the lysosome - Canis familiaris [Reaction:R-RNO-2248891] M6PR transports activated ARSA to the lysosome - Rattus norvegicus
output	[Complex:R-HSA-1606814] active ARSA:Ca2+ [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1614362] SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250393] D'Eustachio, P, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2248891
summation	[Summation:2248892] Activated arylsulfatase A (ARSA) is one of many lysosomal en...
updateTrackers	[UpdateTracker:9842265] Update Tracker - [Reaction:2248891] M6PR transports activated ARSA to the lysosome - v86:[addCatalystActivity, add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9842265] Update Tracker - [Reaction:2248891] M6PR transports activated ARSA to the lysosome - v86:[addCatalystActivity, add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-HSA-9840949] ARSA removes sulfate from SM3 [Reaction:R-HSA-1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide