M6PR transports activated ARSA to the lysosome

Stable Identifier
R-HSA-2248891
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activated arylsulfatase A (ARSA) is one of many lysosomal enzymes bearing phosphomannosyl (M6P) residues. Cation-dependent mannose-6-phosphate receptor (M6PR) binds to M6P on ARSA. The resulting receptor-ligand complex is transported to an acidic pre-lysosomal compartment where the low pH mediates the dissociation of the complex (Stein et al., 1987; Gieselmann et al., 1992).
Literature References
PubMed ID Title Journal Year
1352293 In vitro mutagenesis of potential N-glycosylation sites of arylsulfatase A. Effects on glycosylation, phosphorylation, and intracellular sorting

Gieselmann, V, von Figura, K, Schmidt, B

J Biol Chem 1992
2960521 Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes

Zijderhand-Bleekemolen, JE, Stein, M, von Figura, K, Hasilik, A, Geuze, H

EMBO J 1987
Participants
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Catalyst Activity

protein transporter activity of M6PR [transport vesicle]

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