Reactome | M6PR transports activated ARSA to the lysosome

M6PR transports activated ARSA to the lysosome

Stable Identifier

R-HSA-2248891

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, lysosomal lumen

ReviewStatus

5/5

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M6PR transports activated ARSA to the lysosome

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Activated arylsulfatase A (ARSA) is one of many lysosomal enzymes bearing phosphomannosyl (M6P) residues. Cation-dependent mannose-6-phosphate receptor (M6PR) binds to M6P on ARSA. The resulting receptor-ligand complex is transported to an acidic pre-lysosomal compartment where the low pH mediates the dissociation of the complex (Stein et al., 1987; Gieselmann et al., 1992).

Literature References

PubMed ID	Title	Journal	Year
1352293	In vitro mutagenesis of potential N-glycosylation sites of arylsulfatase A. Effects on glycosylation, phosphorylation, and intracellular sorting Gieselmann, V, Schmidt, B, von Figura, K	J Biol Chem	1992
2960521	Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes Stein, M, Zijderhand-Bleekemolen, JE, Geuze, H, Hasilik, A, von Figura, K	EMBO J	1987