Reactome | ARSA removes sulfate from SM3

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ARSA removes sulfate from SM3 Show undefined attributes

authored	[InstanceEdit:9840940] Stephan, Ralf, 2023-08-02
catalystActivity	[CatalystActivity:1606828] cerebroside-sulfatase activity of active ARSA:Ca2+ [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9840953] Stephan, Ralf, 2023-08-02
dbId	9840949
displayName	ARSA removes sulfate from SM3
edited	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-1606312] GLB1 hydrolyzes SapB/C:LacCer - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-9840879] SM3 [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9840952] Characterization of urinary sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry [LiteratureReference:9840960] Human urinary sulfatides in patients with sulfatidosis (metachromatic leukodystrophy)
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	ARSA removes sulfate from SM3
orthologousEvent	[Reaction:R-SPO-9840949] ARSA removes sulfate from SM3 - Schizosaccharomyces pombe [Reaction:R-GGA-9840949] ARSA removes sulfate from SM3 - Gallus gallus [Reaction:R-XTR-9840949] ARSA removes sulfate from SM3 - Xenopus tropicalis [Reaction:R-SSC-9840949] ARSA removes sulfate from SM3 - Sus scrofa [Reaction:R-BTA-9840949] ARSA removes sulfate from SM3 - Bos taurus [Reaction:R-CFA-9840949] ARSA removes sulfate from SM3 - Canis familiaris [Reaction:R-RNO-9840949] ARSA removes sulfate from SM3 - Rattus norvegicus [Reaction:R-MMU-9840949] ARSA removes sulfate from SM3 - Mus musculus
output	[SimpleEntity:R-ALL-1605601] LacCer [lysosomal lumen] [SimpleEntity:R-ALL-1606845] SO4(2-) [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - Homo sapiens [Reaction:R-HSA-2248891] M6PR transports activated ARSA to the lysosome - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9840949
summation	[Summation:9840950] Sulfated sphingoglycolipid GM3 (SM3, sulfated LacCer, dihexo...

Referrals

(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-HSA-1606312] GLB1 hydrolyzes SapB/C:LacCer