GRB2:SOS1 binds to HBEGF:p-Y-EGFR

Stable Identifier
R-HSA-2179415
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cytoplasmic target proteins containing the SH2 domain can bind to activated EGFR. One such protein, growth factor receptor-bound protein 2 (GRB2), can bind activated EGFR with its SH2 domain whilst in complex with SOS through its SH3 domain. GRB2 can bind at either Y1068 and/or Y1086 autophosphorylation sites on the receptor (Batzer et al. 1994, Okutani et al. 1994).

Literature References
PubMed ID Title Journal Year
7527043 Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells

Okutani, T, Okabayashi, Y, Kido, Y, Sugimoto, Y, Sakaguchi, K, Matuoka, K, Takenawa, T, Kasuga, M

J Biol Chem 1994
7518560 Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

Batzer, AG, Rotin, D, Urena, JM, Skolnik, EY, Schlessinger, J

Mol Cell Biol 1994
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