Reactome | Interaction of SIGLEC14/15/16 and DAP12

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Interaction of SIGLEC14/15/16 and DAP12 Show undefined attributes

authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2172125] Garapati, P V, 2012-03-28
dbId	2172123
displayName	Interaction of SIGLEC14/15/16 and DAP12
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
eventOf	[Pathway:R-HSA-2172127] DAP12 interactions - Homo sapiens
input	[Complex:R-HSA-548940] DAP12 dimer [plasma membrane] [DefinedSet:R-HSA-2326839] SIGLEC14/15/16 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2326793] Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates [LiteratureReference:2326814] SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans [LiteratureReference:2326779] Siglec-15: an immune system Siglec conserved throughout vertebrate evolution
maxDepth	1
modified	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
name	Interaction of SIGLEC14/15/16 and DAP12
orthologousEvent	[Reaction:R-MMU-2172123] Interaction of SIGLEC14/15/16 and DAP12 - Mus musculus [Reaction:R-CFA-2172123] Interaction of SIGLEC14/15/16 and DAP12 - Canis familiaris [Reaction:R-RNO-2172123] Interaction of SIGLEC14/15/16 and DAP12 - Rattus norvegicus
output	[Complex:R-HSA-2326835] SIGLEC14/15/16:DAP12 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-2130151] Dimerization of DAP12 - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2172123
summation	[Summation:2326817] SIGLECs are sialic acid-recognizing receptors of the immunog...

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[Pathway:R-HSA-2172127] DAP12 interactions

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