Reactome | Dimerization of DAP12

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Dimerization of DAP12 Show undefined attributes

authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2130141] Garapati, P V, 2012-02-21
dbId	2130151
displayName	Dimerization of DAP12
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
eventOf	[Pathway:R-HSA-2172127] DAP12 interactions - Homo sapiens
followingEvent	[Reaction:R-HSA-2272668] Interaction of DAP12 and KIR2DS5 - Homo sapiens [Reaction:R-HSA-210298] Interaction of DAP12 and KIR3DS1 - Homo sapiens [Reaction:R-HSA-2272795] Interaction of DAP12 and KIR2DS1 - Homo sapiens [Reaction:R-HSA-2272753] Interaction of DAP12 and KIR2DS4 - Homo sapiens [Reaction:R-HSA-210309] Interaction of DAP12 and KIR2DS2 - Homo sapiens [Reaction:R-HSA-210273] Interaction of DAP12 and NKp44 - Homo sapiens [Reaction:R-HSA-2426569] Interaction of DAP12 and IREM2 - Homo sapiens [Reaction:R-HSA-210274] SIRP beta binds TYROBP - Homo sapiens [Reaction:R-HSA-210292] Interaction of DAP12 and TREM1 - Homo sapiens [Reaction:R-HSA-2172123] Interaction of SIGLEC14/15/16 and DAP12 - Homo sapiens [Reaction:R-HSA-2426566] Interaction of DAP12 and CLM7 - Homo sapiens [Reaction:R-HSA-210271] Interaction of DAP12 and MDL-1 - Homo sapiens [Reaction:R-HSA-210300] Interaction of DAP12 and TREM2 - Homo sapiens [Reaction:R-HSA-2172126] DAP12 interacts with NKG2C - Homo sapiens [Reaction:R-HSA-210295] Interaction of DAP12 and NKG2D - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-198087] TYROBP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2130144] The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site [LiteratureReference:2130153] The structural basis for intramembrane assembly of an activating immunoreceptor complex [LiteratureReference:210108] Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
maxDepth	1
modified	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
name	Dimerization of DAP12
orthologousEvent	[Reaction:R-CFA-2130151] Dimerization of DAP12 - Canis familiaris [Reaction:R-RNO-2130151] Dimerization of DAP12 - Rattus norvegicus [Reaction:R-MMU-2130151] Dimerization of DAP12 - Mus musculus
output	[Complex:R-HSA-548940] DAP12 dimer [plasma membrane]
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130151
summation	[Summation:2130142] DAP12 is expressed as a disulfide-bonded homodimer on NK cel...

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[Pathway:R-HSA-2172127] DAP12 interactions

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