Interaction of SIGLEC14/15/16 and DAP12

Stable Identifier
Homo sapiens
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SIGLECs are sialic acid-recognizing receptors of the immunoglobulin (Ig) superfamily expressed on immune cells. SEGLEC14 and SEGLEC15 preferentially recognise ligands containing the glycans N-acetylneuraminic acid (Neu5Ac). SEGLEC14, SEGLEC15 and SEGLEC16 are expressed by myeloid cells and associate with the activating adapter protein DAP12 via the arginine residue in their transmembrane domains (Angata et al. 2006, Angata et al. 2007, Cao et al. 2008).

Literature References
PubMed ID Title Journal Year
18629938 SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans

Lakner, U, Barrow, AD, Traherne, JA, Cao, H, de Bono, B, Trowsdale, J

Eur. J. Immunol. 2008
17012248 Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates

Nakamura, M, Yamanaka, M, Angata, T, Hayakawa, T, Varki, A

FASEB J. 2006
17483134 Siglec-15: an immune system Siglec conserved throughout vertebrate evolution

Tabuchi, Y, Nakamura, M, Angata, T, Nakamura, K

Glycobiology 2007
Orthologous Events
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