Reactome | Interaction of SIGLEC14/15/16 and DAP12

Interaction of SIGLEC14/15/16 and DAP12

Stable Identifier

R-HSA-2172123

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SIGLECs are sialic acid-recognizing receptors of the immunoglobulin (Ig) superfamily expressed on immune cells. SEGLEC14 and SEGLEC15 preferentially recognise ligands containing the glycans N-acetylneuraminic acid (Neu5Ac). SEGLEC14, SEGLEC15 and SEGLEC16 are expressed by myeloid cells and associate with the activating adapter protein DAP12 via the arginine residue in their transmembrane domains (Angata et al. 2006, Angata et al. 2007, Cao et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18629938	SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans Lakner, U, Barrow, AD, Traherne, JA, Cao, H, de Bono, B, Trowsdale, J	Eur. J. Immunol.	2008
17012248	Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates Nakamura, M, Yamanaka, M, Angata, T, Hayakawa, T, Varki, A	FASEB J.	2006
17483134	Siglec-15: an immune system Siglec conserved throughout vertebrate evolution Tabuchi, Y, Nakamura, M, Angata, T, Nakamura, K	Glycobiology	2007