COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2

Stable Identifier
R-HSA-2162194
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial matrix
Synonyms
DMQ10H2 is hydroxylated to DeMQ10H2 by COQ7
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COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2
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Ubiquinone biosynthesis protein COQ7 homolog (COQ7) (Vajo et al. 1999) catalyses the hydroxylation of 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol (DMQ10H2) to 3-demethylubiquinol-10 (DeMQ10H2). This reaction is inferred from the equivalent reaction in yeast (Marbois & Clarke 1996, Tran et al. 2006). Mitochondrial ubiquinone biosynthesis protein COQ9 is a lipid-binding protein involved in the biosynthesis of coenzyme Q. It binds with COQ7, an interaction that may be necessary to present the lipid to COQ7 activity (Lohman et al. 2014).

Literature References
PubMed ID Title Journal Year
16624818 Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis

Tran, UC, Marbois, B, Gin, P, Gulmezian, M, Jonassen, T, Clarke, CF

J Biol Chem 2006
10501970 Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging

Vajo, Z, King, LM, Jonassen, T, Wilkin, DJ, Ho, N, Munnich, A, Clarke, CF, Francomano, CA

Mamm Genome 1999
25339443 Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis

Lohman, DC, Forouhar, F, Beebe, ET, Stefely, MS, Minogue, CE, Ulbrich, A, Stefely, JA, Sukumar, S, Luna-Sánchez, M, Jochem, A, Lew, S, Seetharaman, J, Xiao, R, Wang, H, Westphall, MS, Wrobel, RL, Everett, JK, Mitchell, JC, López, LC, Coon, JJ, Tong, L, Pagliarini, DJ

Proc. Natl. Acad. Sci. U.S.A. 2014
8621692 The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis

Marbois, BN, Clarke, CF

J Biol Chem 1996
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Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of COQ9 dimer:COQ7:Fe2+ [mitochondrial inner membrane]
Physical Entity
COQ9 dimer:COQ7:Fe2+ [mitochondrial inner membrane]
Activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (0016709)
Inferred From
DMQ6H2 is hydroxylated to DeMQ6H2 by Cat5 (Saccharomyces cerevisiae)
Authored
Williams, MG  (2012-03-19)
Reviewed
Kawamukai, M  (2013-02-05)
Created
Williams, MG  (2012-03-15)
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