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Active PLC-gamma1 dissociates from EGFR
Stable Identifier
R-HSA-212713
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR interacts with phospholipase C-gamma (Homo sapiens)
Active PLC-gamma1 dissociates from EGFR (Homo sapiens)
General
SBML
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BioPAX
Level 2
Level 3
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PDF
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PNG
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PPTX
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once activated PLC-gamma1 dissociates from EGFR, it can hydrolyze PIP2.
Literature References
PubMed ID
Title
Journal
Year
10579907
Phospholipase C-gamma as a signal-transducing element
Ji, Q
,
Carpenter, G
Exp Cell Res
1999
Participants
Input
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
(Homo sapiens)
Output
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Homo sapiens)
p-4Y-PLCG1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
EGFR interacts with phospholipase C-gamma (Homo sapiens)
Orthologous Events
Active PLC-gamma1 dissociates from EGFR (Bos taurus)
Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
Active PLC-gamma1 dissociates from EGFR (Danio rerio)
Active PLC-gamma1 dissociates from EGFR (Drosophila melanogaster)
Active PLC-gamma1 dissociates from EGFR (Gallus gallus)
Active PLC-gamma1 dissociates from EGFR (Mus musculus)
Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)
Active PLC-gamma1 dissociates from EGFR (Sus scrofa)
Active PLC-gamma1 dissociates from EGFR (Xenopus tropicalis)
Authored
Jassal, B (2008-02-13)
Reviewed
Heldin, CH (2008-02-12)
Created
Jassal, B (2008-02-13)
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